Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity
Marc Wadsworth
Travis Hughes
Alex K. Shalek
Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses
Biology
Genomics
Immunology
Infectious DiseaseAlex K. Shalek
Carly Ziegler
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation
GenomicsImmunology
Medicine
José Ordovas-MontañesAlex K. Shalek
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
Alex K. Shalek
Rewiring of the cellular and inter-cellular landscape of the human colon during ulcerative colitis
Biology
Cell Atlas
Computational MethodsImmunologyMedicineJosé Ordovas-MontañesAlex K. Shalek
High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults
Toby Aicher
Sam KazerAlex K. Shalek
Allergic Inflammatory Memory in Human Respiratory Epithelial Progenitor Cells
BiologyCell AtlasImmunologyMedicineJosé Ordovas-Montañes
Sarah NyquistTravis HughesMarc WadsworthSam KazerAlex K. Shalek
A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers
Computational MethodsGenomicsImmunologyInfectious DiseaseMedicine
Kellie KolbJosé Ordovas-MontañesAlex K. Shalek
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells
GenomicsImmunology
Andrew NaviaAlex K. Shalek
Reduced cellular diversity and an altered basal progenitor cell state inform epithelial barrier dysfunction in human type 2 immunity
Cell AtlasImmunologyMedicineJosé Ordovas-MontañesSarah NyquistMarc WadsworthTravis HughesSam KazerAlex K. Shalek
Single-cell analyses to tailor treatments
ImmunologyInfectious DiseaseMedicine
TechnologyAlex K. Shalek
Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies
GenomicsImmunologyInfectious DiseaseMedicine
MicrobiologySam KazerJosé Ordovas-MontañesAlex K. Shalek
IFNγ-Dependent Tissue-Immune Homeostasis is Co-opted in the Tumor Microenvironment
CancerGenomicsImmunology
Jay PrakadanAlex K. Shalek
Circulating CXCR5+CXCR3+PD-1lo Tfh-like Cells in HIV-1 Controllers with Neutralizing Antibody Breadth
BiologyImmunologyInfectious DiseaseKellie KolbAlex K. Shalek
Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion
BiologyImmunologyInfectious DiseaseSam KazerAlex K. Shalek
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
BiologyCancerGenomicsMedicineJay PrakadanMarc Wadsworth
Alex GenshaftTravis HughesCarly ZieglerSam Kazer
Aleth GaillardKellie KolbAlex K. Shalek
Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression
BiologyGenomicsImmunologyInfectious DiseaseSam KazerAlex K. Shalek
A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages
BiologyGenomicsImmunology
R&DTechnologyAlex GenshaftSam KazerAlex K. Shalek
Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity
BiologyGenomicsImmunologyAlex K. Shalek
Oct1 and OCA-B are selectively required for CD4 memory T cell function
BiologyGenomicsImmunologyAlex K. Shalek
Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses
BiologyGenomicsImmunologyInfectious DiseaseMicrobiologyTechnologyAlex K. Shalek
Heterogeneity in immune responses: from populations to single cells
GenomicsImmunologyTechnologyAlex K. Shalek
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
BiologyGenomicsImmunologyAlex K. Shalek
Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli
BiologyImmunologyAlex K. Shalek
Dynamic regulatory network controlling TH17 cell differentiation
BiologyGenomicsImmunologyAlex K. Shalek
Probing Enzymatic Activity inside Living Cells Using a Nanowire−Cell “Sandwich” Assay
Biology
ChemistryImmunologyTechnologyAlex K. Shalek
Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits
GenomicsImmunologyInfectious DiseaseAlex K. Shalek