Ben is a postdoc in the Shalek Lab interested in applying single-cell genomics to improve cellular models of human disease and identify new drug targets and therapeutics. Ben’s research harnesses adult stem cell-derived organoids, particularly from the gastrointestinal tract to advance these next-generation cell models, and has focused on applying these models to inflammatory bowel disease.

Ben spent the first ~22 years of his life in and around Boulder, Colorado, including undergrad in Chemical & Biological Engineering at the University of Colorado Boulder. Deciding that 300+ days of sunshine and a culture of ‘work-life balance’ just wasn’t for him, he moved to Boston and embarked on PhD studies with Jeff Karp (Brigham & Women’s Hospital, Harvard Medical School) and Robert Langer (MIT) through the Harvard-MIT Health Sciences & Technology Program. In addition to research, Ben has a persistent entrepreneurial ‘itch’, including stints with the life sciences venture creation firm, Flagship Pioneering, and the Karp & Langer-founded biotech Frequency Therapeutics. When he’s not thinking about science or startups, Ben enjoys spending time with wife, traveling, and taking in the great outdoors.

Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression
  • Tsankov et al.,
  • Development,
  • 2019
  • Genomics
  • Biology
  • Marc Wadsworth II
  • Sam Allon
  • Ben Mead
  • Riley Drake
  • Alex K. Shalek
Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types
  • Mead B.E.* et al.,
  • BMC Biology,
  • 2018
  • Ben Mead
  • José Ordovas-Montañes
  • Travis Hughes
  • Marc Wadsworth II
  • Alex K. Shalek