Carly Ziegler

Carly Ziegler

Former MD-PhD Student

Degrees & Affiliations

BS, Biology and Mathematics - University of Pennsylvania Medical Student - Harvard Medical School (HST) PhD Candidate, Biophysics - Harvard University

Background & Interests

Cell Atlas Cell Atlas
Computational Methods Computational Methods
Getting Swole Getting Swole
I Want a Hot Body, but I also Want Tacos I Want a Hot Body, but I also Want Tacos
Immunology Immunology
Infectious Disease Infectious Disease
Medicine Medicine
Outdoor Adventures Outdoor Adventures
R&D R&D
Travel Travel

Biography

Carly G. K. Ziegler (Second First Name Gail) was born in Palo Alto, California, and grew up in Decatur, Georgia. Here, she gained a profound appreciation for southern food, hiking the Appalachian trail, and played supporting roles in Atlanta-based MTV reality shows. She majored in Mathematics and Biology at the University of Pennsylvania, and worked with Dr. John Wherry and Dr. David Artis using network modeling to explore the T cell response to infection. Next, she moved to New York City and worked with Dr. Gregoire Altan-Bonnet at Memorial Sloan-Kettering Cancer Center, studying BCR structure and signaling dynamics in B cell neoplasms.

She joined the Harvard/MIT MSTP program in 2014, completed the first 1/2 of medical school within the Harvard-MIT Health Sciences and Technology MD program. She is completing her PhD within the Harvard Biophysics program, and joined the Shalek lab in 2014. Her primary research interests lie in the interaction between host and pathogen, and how single cell RNA-Sequencing can uncover emergent mechanisms of infection and immunity. She is also interested in the development of new technology and new computational tools to weave in metadata (e.g. space, time, interactions) into single cell RNA-Seq datasets.

Carly spends her free time touring Seattle breweries, hiking with her puppies, making feminist cross-stitchings, rock climbing, and being outdoors whenever possible.

Publications

Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response
Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response
  • Rodel et al.,
  • Frontiers in Microbiology,
  • 2021
Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip
Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip
  • Bein et al.,
  • Frontiers in Pharmacology,
  • 2021
Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Medicine Medicine
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Carly Ziegler Carly Ziegler
José Ordovas-Montañes José Ordovas-Montañes
Vincent Miao Vincent Miao
Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes
Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes
  • Genshaft et al.,
  • Nature Communications,
  • 2021
Genomics Genomics
R&D R&D
Technology Technology
Alex Genshaft Alex Genshaft
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Ben Mead Ben Mead
Carly Ziegler Carly Ziegler
Constantine Tzouanas Constantine Tzouanas
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
  • Ziegler et al.,
  • Cell,
  • 2021
Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Carly Ziegler Carly Ziegler
Josh Bromley Josh Bromley
José Ordovas-Montañes José Ordovas-Montañes
Micayla George Micayla George
Riley Drake Riley Drake
Vincent Miao Vincent Miao
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
  • Delorey et al.,
  • Nature,
  • 2021
Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Statistics Statistics
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
  • Muus et al.,
  • Nature Medicine,
  • 2021
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Statistics Statistics
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
Marc Wadsworth II Marc Wadsworth II
Sam Allon Sam Allon
Sarah Nyquist Sarah Nyquist
A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2
A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2
  • Delorey et al.,
  • bioRxiv,
  • 2021
Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Statistics Statistics
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
  • Ziegler et al.,
  • bioRxiv,
  • 2021
Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Carly Ziegler Carly Ziegler
Josh Bromley Josh Bromley
José Ordovas-Montañes José Ordovas-Montañes
Micayla George Micayla George
Riley Drake Riley Drake
Vincent Miao Vincent Miao
Single cell profiling of COVID-19 patients: an international data resource from multiple tissues
Single cell profiling of COVID-19 patients: an international data resource from multiple tissues
  • Chan Zuckerberg Initiative Single-Cell COVID-19 Consortia et al.,
  • medRxiv,
  • 2020
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Carly Ziegler Carly Ziegler
Josh Bromley Josh Bromley
José Ordovas-Montañes José Ordovas-Montañes
Vincent Miao Vincent Miao
Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential
Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential
  • Huang et al.,
  • Cell,
  • 2020
Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
José Ordovas-Montañes José Ordovas-Montañes
Marko Vukovic Marko Vukovic