José Ordovas-Montañes

José Ordovas-Montañes

Former Postdoctoral Fellow

Degrees & Affiliations

BA, Biology - Tufts University PhD, Immunology - Harvard University

Background & Interests

Biology Biology
Cancer Cancer
Cell Atlas Cell Atlas
Immunology Immunology
Microbiology Microbiology
Never a Dull Moment Never a Dull Moment
Top Shelf Top Shelf

Biography

Jose is a second-year Postdoctoral Fellow in the Shalek lab where he is interested in utilizing single-cell genomics to understand the organizing principles of mucosal barrier tissues in health and how to re-balance them in disease. Jose’s research specifically looks at the human gastrointestinal tract and respiratory airways in inflammatory and allergic states, respectively.

Jose grew up in the Boston area, circling the perimeter with high school in Framingham, MA, college at Tufts University, and graduate studies in the Harvard Immunology program. During his undergraduate, Jose worked in human immunology labs at Biogen Idec, University College London, and Children’s Hospital Boston where he focused on monogenic immune deficiencies. For his PhD work, Jose trained with Uli von Andrian studying how the nervous system and the immune system function together as the principal sensory interfaces between the internal and external environment. Due to his problem of reading too much, realizing that this only covered two broad classes of cells, and wanting to return to the human system, he decided to take the plunge into the field of single cell genomics to be able to work on all cell types all the time. Jose is a recently retired amateur bike racer and a perpetually amateur chef.

Publications

Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease
Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease
  • Buchheit et al.,
  • Journal of Allergy and Clinical Immunology,
  • 2023
Biology Biology
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
Marko Vukovic Marko Vukovic
IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease
IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease
  • Buchheit et al.,
  • Journal of Allergy and Clinical Immunology,
  • 2023
Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
Marko Vukovic Marko Vukovic
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation
  • Kummerlowe et al.,
  • Science Translational Medicine,
  • 2022
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Benjamin Doran Benjamin Doran
Conner Kummerlowe Conner Kummerlowe
Ira Fleming Ira Fleming
José Ordovas-Montañes José Ordovas-Montañes
Marc Wadsworth II Marc Wadsworth II
Marko Vukovic Marko Vukovic
Nolawit Mulugeta Nolawit Mulugeta
Toby Aicher Toby Aicher
Travis Hughes Travis Hughes
Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
  • Gideon et al.,
  • Immunity,
  • 2022
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Conner Kummerlowe Conner Kummerlowe
Constantine Tzouanas Constantine Tzouanas
José Ordovas-Montañes José Ordovas-Montañes
Marc Wadsworth II Marc Wadsworth II
Samira Ibrahim Samira Ibrahim
Sarah Nyquist Sarah Nyquist
Travis Hughes Travis Hughes
Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation
Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation
  • Mead et al.,
  • Nature Biomedical Engineering,
  • 2022
Biology Biology
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Medicine Medicine
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Ben Mead Ben Mead
Conner Kummerlowe Conner Kummerlowe
José Ordovas-Montañes José Ordovas-Montañes
Marko Vukovic Marko Vukovic
Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip
Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip
  • Bein et al.,
  • Frontiers in Pharmacology,
  • 2021
Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Medicine Medicine
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Carly Ziegler Carly Ziegler
José Ordovas-Montañes José Ordovas-Montañes
Vincent Miao Vincent Miao
A Treatment-Naive Cellular Atlas of Pediatric Crohn's Disease Predicts Disease Severity and Therapeutic Response
A Treatment-Naive Cellular Atlas of Pediatric Crohn's Disease Predicts Disease Severity and Therapeutic Response
  • Zheng et al.,
  • bioRxiv,
  • 2021
Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Benjamin Doran Benjamin Doran
José Ordovas-Montañes José Ordovas-Montañes
Kyle Kimler Kyle Kimler
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
  • Ziegler et al.,
  • Cell,
  • 2021
Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Carly Ziegler Carly Ziegler
Josh Bromley Josh Bromley
José Ordovas-Montañes José Ordovas-Montañes
Micayla George Micayla George
Riley Drake Riley Drake
Vincent Miao Vincent Miao
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation in severe disease
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation in severe disease
  • Kummerlowe et al.,
  • bioRxiv,
  • 2021
Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Benjamin Doran Benjamin Doran
Conner Kummerlowe Conner Kummerlowe
Ira Fleming Ira Fleming
José Ordovas-Montañes José Ordovas-Montañes
Marko Vukovic Marko Vukovic
Nolawit Mulugeta Nolawit Mulugeta
Travis Hughes Travis Hughes
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
  • Dwyer et al.,
  • Science Immunology,
  • 2021
Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
Marko Vukovic Marko Vukovic
Sam Allon Sam Allon
Sarah Nyquist Sarah Nyquist
Travis Hughes Travis Hughes