Biography

Jose is a second-year Postdoctoral Fellow in the Shalek lab where he is interested in utilizing single-cell genomics to understand the organizing principles of mucosal barrier tissues in health and how to re-balance them in disease. Jose’s research specifically looks at the human gastrointestinal tract and respiratory airways in inflammatory and allergic states, respectively.

Jose grew up in the Boston area, circling the perimeter with high school in Framingham, MA, college at Tufts University, and graduate studies in the Harvard Immunology program. During his undergraduate, Jose worked in human immunology labs at Biogen Idec, University College London, and Children’s Hospital Boston where he focused on monogenic immune deficiencies. For his PhD work, Jose trained with Uli von Andrian studying how the nervous system and the immune system function together as the principal sensory interfaces between the internal and external environment. Due to his problem of reading too much, realizing that this only covered two broad classes of cells, and wanting to return to the human system, he decided to take the plunge into the field of single cell genomics to be able to work on all cell types all the time. Jose is a recently retired amateur bike racer and a perpetually amateur chef.

Publications

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation
  • Biton et al.,
  • Cell,
  • 2018
  • Medicine
  • Immunology
  • Genomics
  • José Ordovas-Montañes
  • Alex K. Shalek
Rewiring of the cellular and inter-cellular landscape of the human colon during ulcerative colitis
  • Smillie et al.,
  • BioRxiv,
  • 2018
  • Biology
  • Cell Atlas
  • Immunology
  • Computational Methods
  • Medicine
  • José Ordovas-Montañes
  • Alex K. Shalek
Allergic Inflammatory Memory in Human Respiratory Epithelial Progenitor Cells
  • Ordovas-Montanes J. et al.,
  • Nature,
  • 2018
  • Medicine
  • Biology
  • Immunology
  • Cell Atlas
  • José Ordovas-Montañes
  • Sarah Nyquist
  • Travis Hughes
  • Marc Wadsworth
  • Sam Kazer
  • Alex K. Shalek
Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types
  • Mead B.E.* et al.,
  • BMC Biology,
  • 2018
  • José Ordovas-Montañes
  • Travis Hughes
  • Marc Wadsworth
  • Alex K. Shalek
A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers
  • Martin-Gayo et al.,
  • Genome Biology,
  • 2018
  • Medicine
  • Computational Methods
  • Genomics
  • Immunology
  • Infectious Disease
  • Kellie Kolb
  • José Ordovas-Montañes
  • Alex K. Shalek
Reduced cellular diversity and an altered basal progenitor cell state inform epithelial barrier dysfunction in human type 2 immunity
  • Jose Ordovas-Montanes et al.,
  • BioRxiv,
  • 2017
  • Immunology
  • Medicine
  • Cell Atlas
  • José Ordovas-Montañes
  • Sarah Nyquist
  • Marc Wadsworth
  • Travis Hughes
  • Sam Kazer
  • Alex K. Shalek
Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies
  • Nandin I.S. et al.,
  • Journal of Experimental Medicine,
  • 2017
  • Genomics
  • Medicine
  • Microbiology
  • Infectious Disease
  • Immunology
  • Sam Kazer
  • José Ordovas-Montañes
  • Alex K. Shalek