Riley Drake

Riley Drake

Former Research Technician

Degrees & Affiliations

BA, Biology - Boston College

Background & Interests

Cancer Cancer
Immunology Immunology
Making Waves Making Waves
Outdoor Adventures Outdoor Adventures
R&D R&D
Travel Travel

Biography

Riley Drake is an graduate of Boston College where she studied Biology.  Riley is interested in applying single-cell genomics to study interactions between cancer and the immune system in the context of the tumor microenvironment.  Riley utilizes currently existing technologies to profile tumors; she also hopes to optimize processing protocols for preserving the transcriptional profiles of resected tissues, allowing them to be profiled at a later date.

Before moving to Boston for school, Riley did two rotations in the Powell Lab at Johns Hopkins University where she studied the role of the mTOR-pathway on the differentiation, and metabolic tendencies, of different helper T cell subsets.  She spent her rotation in Lauer Lab at Massachusetts General Hospital drinking lots of espresso and studying the effect of Hepatitis-C infection on the proliferation and functionality of CD8 killer T cells.  Cohosted in the Lander and Sabatini Labs, Riley attempted to CRISPr to identify genes essential of the survival of Chronic Myeloid Leukemia (CML).   On weekends, Riley can be found taking pictures, climbing rocks, crawling through caves or coordinating educational programs.

Publications

scRNA-Seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with clinical malaria
scRNA-Seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with clinical malaria
  • Morang’a et al.,
  • medRxiv,
  • 2023
Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Riley Drake Riley Drake
Vincent Miao Vincent Miao
Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients
Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients
  • Genshaft et al.,
  • Hepatology,
  • 2023
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
R&D R&D
Technology Technology
Alex Genshaft Alex Genshaft
Alex K. Shalek Alex K. Shalek
Constantine Tzouanas Constantine Tzouanas
Ira Fleming Ira Fleming
Jasmin Joseph-Chazan Jasmin Joseph-Chazan
Mike Vilme Mike Vilme
Nancy Tran Nancy Tran
Riley Drake Riley Drake
Vitrification preserves murine ovarian follicular cell transcriptome in a 3D encapsulated in vitro follicle growth system
Vitrification preserves murine ovarian follicular cell transcriptome in a 3D encapsulated in vitro follicle growth system
  • Wang et al.,
  • Biology of Reproduction,
  • 2023
Biology Biology
Genomics Genomics
Immunology Immunology
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Brittany Goods Brittany Goods
Daniela Russo Daniela Russo
Riley Drake Riley Drake
Single-cell transcriptomics of staged oocytes and somatic cells reveal novel regulators of follicle activation
Single-cell transcriptomics of staged oocytes and somatic cells reveal novel regulators of follicle activation
  • Chen et al.,
  • Reproduction,
  • 2023
Biology Biology
Genomics Genomics
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Brittany Goods Brittany Goods
Daniela Russo Daniela Russo
Riley Drake Riley Drake
Cellular and transcriptional diversity over the course of human lactation
Cellular and transcriptional diversity over the course of human lactation
  • Nyquist et al.,
  • PNAS,
  • 2022
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Ben Mead Ben Mead
Brittany Goods Brittany Goods
Kellie Kolb Kellie Kolb
Patricia Gao Patricia Gao
Riley Drake Riley Drake
Sarah Nyquist Sarah Nyquist
Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity
Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity
  • Genshaft et al.,
  • bioRxiv,
  • 2021
Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
R&D R&D
Technology Technology
Alex Genshaft Alex Genshaft
Alex K. Shalek Alex K. Shalek
Constantine Tzouanas Constantine Tzouanas
Ira Fleming Ira Fleming
Jasmin Joseph-Chazan Jasmin Joseph-Chazan
Mike Vilme Mike Vilme
Nancy Tran Nancy Tran
Riley Drake Riley Drake
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
  • Ziegler et al.,
  • Cell,
  • 2021
Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Carly Ziegler Carly Ziegler
Josh Bromley Josh Bromley
José Ordovas-Montañes José Ordovas-Montañes
Micayla George Micayla George
Riley Drake Riley Drake
Vincent Miao Vincent Miao
Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu
Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu
  • Goods et al.,
  • JCI Insight,
  • 2021
Biology Biology
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Brittany Goods Brittany Goods
Ira Fleming Ira Fleming
Riley Drake Riley Drake
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
  • Ziegler et al.,
  • bioRxiv,
  • 2021
Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Carly Ziegler Carly Ziegler
Josh Bromley Josh Bromley
José Ordovas-Montañes José Ordovas-Montañes
Micayla George Micayla George
Riley Drake Riley Drake
Vincent Miao Vincent Miao
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage
  • Askenase et al.,
  • Science Immunology,
  • 2021
Biology Biology
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Brittany Goods Brittany Goods
James Gatter James Gatter
Riley Drake Riley Drake
Shaina Carroll Shaina Carroll