Biography

Sam Kazer is a 3rd year graduate student in the Shalek Lab interested in applying single-cell genomics to tackle problems in infectious disease and allergy. Sam’s research focuses on understanding host-pathogen interactions in HIV infection in humans on a system-wide level; he collaborates widely throughout the Ragon Institute of MGH, Harvard, and MIT and at the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH). 

Sam’s optimistic, but Type-A, attitude was forged through a childhood in the fast-paced cutthroat Long Island, NY suburbs followed by a mellowing high school experience in Denver, CO. Attending Columbia University for his B.A. in Physical Chemistry, Sam worked for three years with Professor Kenneth Eisenthal utilizing non-linear spectroscopy to probe DNA-protein interactions in a label free environment. Following his undergraduate work, he enrolled in the Department of Chemistry at MIT in a Ph.D. program under Alex Shalek. Sam is lapsed photographer, frequent trivia-goer, and all around food lover.

Publications

Reduced cellular diversity and an altered basal progenitor cell state inform epithelial barrier dysfunction in human type 2 immunity
  • Jose Ordovas-Montanes et al.,
  • BioRxiv,
  • 2017
  • Medicine
  • Cell Atlas
  • Immunology
  • José Ordovas-Montañes
  • Sarah Nyquist
  • Marc Wadsworth
  • Travis Hughes
  • Sam Kazer
  • Alex K. Shalek
Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion
  • Ranasinghe et al.,
  • Immunity,
  • 2016
  • Infectious Disease
  • Immunology
  • Biology
  • Sam Kazer
  • Alex K. Shalek
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
  • Tirosh et al.,
  • Science,
  • 2016
  • Biology
  • Medicine
  • Cancer
  • Genomics
  • Jay Prakadan
  • Marc Wadsworth
  • Alex Genshaft
  • Travis Hughes
  • Carly Ziegler
  • Sam Kazer
  • Aleth Gaillard
  • Kellie Kolb
  • Alex K. Shalek
Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM
  • Wong et al.,
  • PNAS,
  • 2016
  • Technology
  • Genomics
  • Chemistry
  • Sam Kazer
  • Aleth Gaillard
  • Alex K. Shalek
Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression
  • Kløverpris et al.,
  • Immunity,
  • 2016
  • Genomics
  • Infectious Disease
  • Biology
  • Immunology
  • Sam Kazer
  • Alex K. Shalek
A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages
  • Kimmerling et al.,
  • Nat. Commun.,
  • 2016
  • Technology
  • Genomics
  • Biology
  • R&D
  • Immunology
  • Alex Genshaft
  • Sam Kazer
  • Alex K. Shalek