Sam Kazer

Sam Kazer

Former Graduate Student

Degrees & Affiliations

BA, Physical Chemistry - Columbia University PhD Candidate, Chemistry - MIT

Background & Interests

Chemistry Chemistry
Genomics Genomics
I Want a Hot Body, but I also Want Tacos I Want a Hot Body, but I also Want Tacos
Immunology Immunology
Infectious Disease Infectious Disease
Low Braü Low Braü
Make Way for Dumplings Make Way for Dumplings
Never a Dull Moment Never a Dull Moment

Biography

Sam Kazer is a 5th year graduate candidate in the Shalek Lab interested in applying single-cell genomics to tackle problems in infectious disease and allergy. Sam’s research focuses on understanding host-pathogen interactions in HIV infection in humans on a system-wide level; he collaborates widely throughout the Ragon Institute of MGH, Harvard, and MIT and at the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH). 

Sam’s optimistic, but Type-A, attitude was forged through a childhood in the fast-paced cutthroat Long Island, NY suburbs followed by a mellowing high school experience in Denver, CO. Attending Columbia University for his B.A. in Physical Chemistry, Sam worked for three years with Professor Kenneth Eisenthal utilizing non-linear spectroscopy to probe DNA-protein interactions in a label free environment. Following his undergraduate work, he enrolled in the Department of Chemistry at MIT in a Ph.D. program under Alex Shalek. Sam is lapsed photographer, frequent trivia-goer, and all around food lover.

Publications

Pro-inflammatory feedback loops define immune responses to pathogenic Lentivirus infection
Pro-inflammatory feedback loops define immune responses to pathogenic Lentivirus infection
  • Wilk et al.,
  • Genome Medicine,
  • 2024
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Ira Fleming Ira Fleming
Jennyfer Galvez-Reyes Jennyfer Galvez-Reyes
Sam Kazer Sam Kazer
Vincent Miao Vincent Miao
Pro-inflammatory feedback loops define immune responses to pathogenic lentivirus infection
Pro-inflammatory feedback loops define immune responses to pathogenic lentivirus infection
  • Wilk et al.,
  • bioRxiv,
  • 2023
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Ira Fleming Ira Fleming
Jennyfer Galvez-Reyes Jennyfer Galvez-Reyes
Sam Kazer Sam Kazer
Vincent Miao Vincent Miao
HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control
HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control
  • Fardoos et al.,
  • Frontiers in Immunology,
  • 2023
Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
Sarah Nyquist Sarah Nyquist
Son Nguyen Son Nguyen
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
  • Amoozgar et al.,
  • Nature Communications,
  • 2021
Cancer Cancer
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection
MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection
  • Khuzwayo et al.,
  • Frontiers in Immunology,
  • 2021
Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Jay Prakadan Jay Prakadan
Sam Kazer Sam Kazer
Evolution and diversity of immune responses during acute HIV infection
Evolution and diversity of immune responses during acute HIV infection
  • Kazer et al.,
  • Immunity,
  • 2020
Biology Biology
Immunology Immunology
Infectious Disease Infectious Disease
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy
Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy
  • Singh et al.,
  • Cell Reports,
  • 2020
Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
A Single Human VH-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood
A Single Human VH-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood
  • Sangesland et al.,
  • Cell Reports,
  • 2020
Biology Biology
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
James Gatter James Gatter
Sam Kazer Sam Kazer
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
  • Ziegler et al.,
  • Cell,
  • 2020
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Statistics Statistics
Ben Mead Ben Mead
Benjamin Doran Benjamin Doran
Carly Ziegler Carly Ziegler
Constantine Tzouanas Constantine Tzouanas
James Gatter James Gatter
Marc Wadsworth II Marc Wadsworth II
Marko Vukovic Marko Vukovic
Sam Allon Sam Allon
Sarah Nyquist Sarah Nyquist
Vincent Miao Vincent Miao
Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection
Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection
  • Kazer et al.,
  • Nature Medicine,
  • 2020
Biology Biology
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Statistics Statistics
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
José Ordovas-Montañes José Ordovas-Montañes
Sam Kazer Sam Kazer
Sarah Nyquist Sarah Nyquist
Shaina Carroll Shaina Carroll
Toby Aicher Toby Aicher
Vincent Miao Vincent Miao