Biography

Travis is an MD-PhD student in the Shalek Lab pursuing an MD in HST and a PhD in the Harvard Immunology program. He is broadly interested in developing and applying single-cell technologies to understand cellular ecology in health and disease. Current projects include developing improvements and extensions of the Seq-Well platform, and he is working on a large project aimed to understand the cellular ecology of M. tuberculosis granulomas.

Travis is a native of Oklahoma and did his undergraduate work in Biology at Oklahoma Christian University. During college, he co-founded a non-profit organization called Wishing Well, which raises money for water projects. After graduation, he spent time working on international development projects in Rwanda and Uganda before returning to Oklahoma to begin work in the lab of Amr Sawalha at the Oklahoma Medical Research Foundation. Travis obtained a MPH in Epidemiology and International Health at the University of Michigan, Ann Arbor. Prior to coming to HMS and MIT, he spent an additional year in the lab working on autoimmune genetics, while simultaneously working as a live-in caregiver for a man living with multiple sclerosis. In his spare time, Travis enjoys reading, sailing, amateur mixology, pottery, and analog photography.

 

Publications

Single-cell profiling of Ebola virus infection ​in vivo​ reveals viral and host transcriptional dynamics
  • Kotliar et al.,
  • bioRxiv,
  • 2020
  • Genomics
  • Biology
  • Immunology
  • Infectious Disease
  • Travis Hughes
  • Marc Wadsworth II
  • Nancy Tran
  • Alex K. Shalek
Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary disease
  • Bassler et al.,
  • bioRxiv,
  • 2020
  • Genomics
  • Medicine
  • Immunology
  • Computational Methods
  • Marc Wadsworth II
  • Travis Hughes
  • Alex K. Shalek
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
  • Ziegler et al.,
  • Cell,
  • 2020
  • Statistics
  • Cell Atlas
  • Biology
  • Infectious Disease
  • Genomics
  • Immunology
  • Carly Ziegler
  • Sam Allon
  • Sarah Nyquist
  • Vincent Miao
  • Constantine Tzouanas
  • Marc Wadsworth II
  • Sam Kazer
  • Travis Hughes
  • Benjamin Doran
  • James Gatter
  • Marko Vukovic
  • Ben Mead
  • Shaina Carroll
  • Alex K. Shalek
  • José Ordovas-Montañes
Systematic comparison of single-cell and single-nucleus RNA-sequencing methods
  • Ding et al.,
  • Nature Biotechnology,
  • 2020
  • Computational Methods
  • Technology
  • R&D
  • Genomics
  • Travis Hughes
  • Marc Wadsworth II
  • Shaina Carroll
  • Alex K. Shalek
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is enriched in specific cell subsets across tissues
  • Ziegler et al.,
  • SSRN,
  • 2020
  • Immunology
  • Infectious Disease
  • Cell Atlas
  • Biology
  • Computational Methods
  • Genomics
  • Medicine
  • Carly Ziegler
  • Sam Allon
  • Sarah Nyquist
  • Vincent Miao
  • Marc Wadsworth II
  • Sam Kazer
  • Travis Hughes
  • Benjamin Doran
  • James Gatter
  • Marko Vukovic
  • Constantine Tzouanas
  • Shaina Carroll
  • Alex K. Shalek
  • José Ordovas-Montañes
Prevention of tuberculosis in macaques after intravenous BCG immunization
  • Darrah et al.,
  • Nature,
  • 2020
  • Immunology
  • Medicine
  • Infectious Disease
  • Genomics
  • Biology
  • Marc Wadsworth II
  • Travis Hughes
  • Alex K. Shalek
Highly efficient, massively-parallel single-cell RNA-Seq reveals cellular states and molecular features of human skin pathology
  • Hughes T.K. et al.,
  • bioRxiv,
  • 2019
  • Technology
  • Biology
  • Genomics
  • Immunology
  • R&D
  • Travis Hughes
  • Marc Wadsworth II
  • José Ordovas-Montañes
  • Alex K. Shalek
Seq-Well: A Sample-Efficient, Portable Picowell Platform for Massively Parallel Single-Cell RNA Sequencing
  • Aicher et al.,
  • Single-Cell Methods,
  • 2019
  • R&D
  • Technology
  • Toby Aicher
  • Shaina Carroll
  • Marc Wadsworth II
  • Travis Hughes
  • Alex K. Shalek
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity
  • van Galen et al.,
  • Cell,
  • 2019
  • Marc Wadsworth II
  • Travis Hughes
  • Alex K. Shalek
Allergic Inflammatory Memory in Human Respiratory Epithelial Progenitor Cells
  • Ordovas-Montanes et al.,
  • Nature,
  • 2018
  • Immunology
  • Biology
  • Cell Atlas
  • Medicine
  • José Ordovas-Montañes
  • Sarah Nyquist
  • Marko Vukovic
  • Marc Wadsworth II
  • Travis Hughes
  • Sam Kazer
  • Alex K. Shalek
Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types
  • Mead B.E.* et al.,
  • BMC Biology,
  • 2018
  • Ben Mead
  • José Ordovas-Montañes
  • Travis Hughes
  • Marc Wadsworth II
  • Alex K. Shalek
Reduced cellular diversity and an altered basal progenitor cell state inform epithelial barrier dysfunction in human type 2 immunity
  • Jose Ordovas-Montanes et al.,
  • BioRxiv,
  • 2017
  • Immunology
  • Medicine
  • Cell Atlas
  • José Ordovas-Montañes
  • Sarah Nyquist
  • Marc Wadsworth II
  • Travis Hughes
  • Sam Kazer
  • Alex K. Shalek
Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput
  • Gierahn et al.,
  • Nature Methods,
  • 2017
  • Genomics
  • Chemistry
  • Travel
  • R&D
  • Technology
  • Marc Wadsworth II
  • Travis Hughes
  • Alex K. Shalek
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
  • Tirosh et al.,
  • Science,
  • 2016
  • Medicine
  • Biology
  • Genomics
  • Cancer
  • Jay Prakadan
  • Marc Wadsworth II
  • Alex Genshaft
  • Travis Hughes
  • Carly Ziegler
  • Sam Kazer
  • Aleth Gaillard
  • Kellie Kolb
  • Alex K. Shalek
Marrying microfluidics and microwells for parallel, high-throughput single-cell genomics
  • Wadsworth II et al.,
  • Genome Biology,
  • 2015
  • R&D
  • Technology
  • Genomics
  • Marc Wadsworth II
  • Travis Hughes
  • Alex K. Shalek