Paired Single-cell Transcriptome-TCR Methods in Nature Immunology

Paired Single-cell Transcriptome-TCR Methods in Nature Immunology

Nov 19, 2019

Our recent paper details a strategy, co-developed with the Love Lab at MIT, for pairing TCR sequencing with whole-transcriptome profiling in single-cells via 3′-barcoded techniques. Using a targeted pulldown and amplification method, we are able to sequence TCR CDR3 regions from pre-existing scRNA-seq libraries, increasing the amount of orthogonal information recoverable from archived samples. Read […]

New Paper on Neuroimmune Interactions on BioRxiv

New Paper on Neuroimmune Interactions on BioRxiv

Nov 13, 2019

We’re stoked to have this paper up! We present our work finding new roles for sensory neurons within inflammatory responses and previously unappreciated axes of neuro-immune crosstalk. Led by Shalek lab MD-PhD student Carly Ziegler and post doc Tracy Huang with Uli von Andrian, we find that lymph nodes are not only innervated by sensory […]

Alex Shalek Featured in Nature Methods: “Voices in Methods Development”

Alex Shalek Featured in Nature Methods: “Voices in Methods Development”

Oct 04, 2019

Alex was recently featured in Nature Methods to discuss challenges and future opportunities in high-throughput genomics techniques. He joins researchers spanning across the spectrum of biology disciplines in laying out technological challenges of their respective fields and the great potential next-generation techniques hold in better understanding complex biological systems. Read Alex’s vision and those of […]

Human Cell Atlas Launches in Latin America

Human Cell Atlas Launches in Latin America

Sep 11, 2019

Alex was recently in Sao Paulo to kick off work with the the Human Cell Atlas in Latin America. Alongside both Brazilian and international researchers, Alex introduced the scope and potential impact of the initiative, which seeks to create comprehensive reference maps of all human cells—the fundamental units of life—as a basis for both understanding human […]

Kellie Kolb Graduates from the Shalek Lab!

Kellie Kolb Graduates from the Shalek Lab!

Jun 06, 2019

Congratulations to Kellie Kolb, the first student from the Shalek Lab to receive her PhD! We wish Kellie the best of luck in her future endeavors, and we’re excited for many more graduations in the coming years!

Our Paper on Tuberculosis Infection Featured in NIH News

Our Paper on Tuberculosis Infection Featured in NIH News

Jun 06, 2019

A recent paper published in Nature from the Shalek lab and collaborators was featured in NIH News. Ardain et. al. demonstrate that group 3 innate lymphoid cells localize to the lungs soon after M. tuberculosis infection, providing an early line of defense against tuberculosis (TB). This understanding of the initial immune response to TB may […]

Alex Shalek Featured in Immunity Voices: “The Next Quarter Century”

Alex Shalek Featured in Immunity Voices: “The Next Quarter Century”

Apr 17, 2019

Immunity celebrates its 25th anniversary at an exciting time in immunology, marked by the advent of new, door-opening approaches and a deeper understanding of the centrality of the immune system to both health and disease. Alex is among 25 investigators asked to look forward and share a vision of the next quarter century of immunology […]

Alex Shalek Promoted to Associate Professor without Tenure!

Alex Shalek Promoted to Associate Professor without Tenure!

Feb 06, 2019

Alex K. Shalek has been approved for promotion to Associate Professor without Tenure! The official promotion will be effective July 1. Congratulations Alex! Alex’s research is directed towards the creation and implementation of new technologies to understand how cells collectively perform systems-level functions in healthy and diseased states. His lab’s technology development efforts leverage recent […]