Our improvements to the Seq-Well scRNA-seq platform were release today – read the publication in Immunity here and the press release here....
Seq-Well S^3 Released
HCA Equity Working Group Leaders Share Lessons Learned
Alex, along with HCA Equity Working Group co-leaders Partha Majumder and Musa Mhlanga, details some of the lessons they’ve learned in their timing leading the initiative and their thoughts moving forward in this piece for Nature Medicine....
Alex Recipient of HMS Young Mentor Award!
Congratulations to Alex for being awarded a Young Mentor Award from Harvard Medical School! Read more here....
Alex Outlines Recommendation Letter Process
Alex was recently featured in Nature on how he approaches writing recommendation letters for his trainees and students. Read it here!...
Constantine Named 2020 Hertz Fellow!
Our very own Constantine Tzouanas has been named a 2020 Hertz Fellow! We’re very excited for this achievement, and looking forward to what’s in store. Read more about the Hertz Fellowship and Constantine here....
Partnership with Chan Zuckerberg Initiative to Profile Pediatric COVID-19 Announced
With Boston Children’s Hospital PI (and former post-doc!) Jose Ordovas-Montanes, we will expand our COVID-19-related research to include understanding disease pathogenesis in a pediatric cohort – the data and findings of which will be readily accessible to the scientific community....
Alex Wins Edgerton Faculty Award!
Congratulations to Alex for winning the 2019-2020 Harold E. Edgerton Faculty Achievement Award, given for “his leadership and pioneering spirit; his vision, inventiveness, and enthusiasm for mentorship and collaboration; and his tremendous contributions to a critical area at the intersection...
Study Describing ACE2 as an Interferon-Stimulated Gene Out in Cell
Our study showing ACE2, the entry receptor for SARS-CoV-2, as an interferon-stimulated gene is now out in Cell here. Read about the study in The Boston Globe and MIT News, C&EN, NIH Director’s blog, among others. Datasets analyzed in this...
New Study on Immune Dynamics in Untreated HIV-1 Infection Now Out
Our study of untreated HIV-1 infection is now out in Nature Medicine! We profile longitudinal peripheral blood samples from pre-infection through chronic infection to characterize gene programs that are temporally-correlated in and between cell types. Read the press release here....
Pre-print Detailing ACE2 as an Interferon-Stimulated Gene Now Available
Our pre-print work detailing ACE2 upregulation in response to interferons, and type I interferons in particular, is now available here. Descriptions of the datasets analyzed in the study are found here on our COVID-19 Resource page, along with links to...
COVID-19 scRNA-seq Resource Datasets Released
In light of the spread of SARS-CoV-2, we are sharing multiple unpublished and published scRNA-seq datasets across both health and disease that harbor cells expressing ACE2 (the gene encoding the host receptor) and TMPRSS2 (the gene involved in processing the...
Marc Wadsworth Graduates from the Shalek Lab!
A belated congratulations to Marc Wadsworth for successfully defending his thesis! We wish Marc the best of luck in his future endeavors, and we’re excited for all the upcoming defenses this semester!...
TB Vaccine Efficacy Study Previewed in Cell
Our recent publication on increased tuberculosis vaccine efficacy via alternative administration routes is previewed here in Cell. Read the paper here....
New Study on a Master Regulator in Toxoplasma Infection Now Out
With collaborators in the Lourido lab, our paper on a master regulator for the differentiation of Toxoplasma gondii from its acute- to chronic-stage form is now out in Cell. Read press releases about the study here and here....
Jay Prakadan Graduates from the Shalek Lab!
Congratulations to Jay Prakadan for successfully defending his thesis! We wish Jay the best of luck in his future endeavors, and we’re excited for all the upcoming defenses this year!...
New Study on Increased TB Vaccine Efficacy Now Out
Our paper on increased tuberculosis (TB) vaccine efficacy with intravenous injection in nonhuman primates is now out in Nature. With collaborators at the National Institutes of Health’s National Institute of Allergy and Infectious Diseases and others, we show greatly enhanced...