2023 - Shalek Lab

Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis

Corleis et al.,
Science Translational Medicine,
2023

Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival

Tzouanas et al.,
bioRxiv,
2023

Natural history of Ebola virus disease in rhesus monkeys shows viral variant emergence dynamics and tissue-specific host responses

Normandin et al.,
Cell Genomics,
2023

Identification of drug candidates targeting monocyte reprogramming in people living with HIV

Knoll et al.,
Frontiers in Immunology,
2023

CD8+ lymphocytes are critical for early control of tuberculosis in macaques

Winchell et al.,
Journal of Experimental Medicine,
2023

scRNA-Seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with clinical malaria

Morang’a et al.,
medRxiv,
2023

Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients

Genshaft et al.,
Hepatology,
2023

Comparative analysis of cell–cell communication at single-cell resolution

Wilk et al.,
Nature Biotechnology,
2023

Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation

Bhagchandani et al.,
Science Advances,
2023

PI3Kβ controls immune evasion in PTEN-deficient breast tumours

Bergholz et al.,
Nature,
2023

Pro-inflammatory feedback loops define immune responses to pathogenic lentivirus infection

Wilk et al.,
bioRxiv,
2023

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Crouchet et al.,
Nature Communications,
2023

Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease

Buchheit et al.,
Journal of Allergy and Clinical Immunology,
2023

An ex vivo ovulation system enables the discovery of novel ovulatory pathways and nonhormonal contraceptive candidates

Zhang et al.,
Biology of Reproduction,
2023

Vitrification preserves murine ovarian follicular cell transcriptome in a 3D encapsulated in vitro follicle growth system

Wang et al.,
Biology of Reproduction,
2023

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

Bui et al.,
Nature Communications,
2023

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

Bernardes et al.,
Immunity,
2023

Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2–Mediated Myocarditis

Tucker et al.,
Circulation,
2023

IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease

Buchheit et al.,
Journal of Allergy and Clinical Immunology,
2023

Compressed phenotypic screens for complex multicellular models and high-content assays

Mead et al.,
bioRxiv,
2023

Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity

Williams et al.,
Cancer Research,
2023

NIAID Workshop on T Cell Technologies

Gondré-Lewis et al.,
Nature Immunology,
2023

Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis)

Jaiswal et al.,
BMC Genomics,
2023

HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control

Fardoos et al.,
Frontiers in Immunology,
2023

Single-cell transcriptomics of staged oocytes and somatic cells reveal novel regulators of follicle activation

Chen et al.,
Reproduction,
2023

Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells

Morris et al.,
Cell Reports,
2023

Single-Cell Multiomics Reveals Clonal T-Cell Expansions and Exhaustion in Blastic Plasmacytoid Dendritic Cell Neoplasm

DePasquale et al.,
Frontiers in Immunology,
2023

Identification and tracking of alloreactive T cell clones in Rhesus Macaques through the RM-scTCR-Seq platform

Gerdemann et al.,
Frontiers in Immunology,
2023

PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment

Collins et al.,
Journal for Immunotherapy of Cancer,
2023

Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis

Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival

Natural history of Ebola virus disease in rhesus monkeys shows viral variant emergence dynamics and tissue-specific host responses

Identification of drug candidates targeting monocyte reprogramming in people living with HIV

CD8+ lymphocytes are critical for early control of tuberculosis in macaques

scRNA-Seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with clinical malaria

Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients

Comparative analysis of cell–cell communication at single-cell resolution

Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation

PI3Kβ controls immune evasion in PTEN-deficient breast tumours

Pro-inflammatory feedback loops define immune responses to pathogenic lentivirus infection

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease

An ex vivo ovulation system enables the discovery of novel ovulatory pathways and nonhormonal contraceptive candidates

Vitrification preserves murine ovarian follicular cell transcriptome in a 3D encapsulated in vitro follicle growth system

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2–Mediated Myocarditis

IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease

Compressed phenotypic screens for complex multicellular models and high-content assays

Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity

NIAID Workshop on T Cell Technologies

Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis)

HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control

Single-cell transcriptomics of staged oocytes and somatic cells reveal novel regulators of follicle activation

Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells

Single-Cell Multiomics Reveals Clonal T-Cell Expansions and Exhaustion in Blastic Plasmacytoid Dendritic Cell Neoplasm

Identification and tracking of alloreactive T cell clones in Rhesus Macaques through the RM-scTCR-Seq platform

PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment

Topic

By Year