Cancer Archives - Shalek Lab

Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment

Yeo et al.,
Cell Reports Medicine,
2024

Glycan-costumed virus-like particles promote type 1 anti-tumor immunity

Lensch et al.,
biorxiv,
2024

Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation

Bhagchandani et al.,
Science Advances,
2023

PI3Kβ controls immune evasion in PTEN-deficient breast tumours

Bergholz et al.,
Nature,
2023

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Crouchet et al.,
Nature Communications,
2023

Compressed phenotypic screens for complex multicellular models and high-content assays

Mead et al.,
bioRxiv,
2023

Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity

Williams et al.,
Cancer Research,
2023

Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells

Morris et al.,
Cell Reports,
2023

Single-Cell Multiomics Reveals Clonal T-Cell Expansions and Exhaustion in Blastic Plasmacytoid Dendritic Cell Neoplasm

DePasquale et al.,
Frontiers in Immunology,
2023

PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment

Collins et al.,
Journal for Immunotherapy of Cancer,
2023

Deciphering the immunopeptidome in vivo reveals new tumour antigens

Jaeger et al.,
Nature,
2022

Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states

Song et al.,
Nature Communications,
2022

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

Raghavan et al.,
Cell,
2021

Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice

Hamza et al.,
Nature Communications,
2021

Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases

Prakadan et al.,
Nature Communications,
2021

Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

Amoozgar et al.,
Nature Communications,
2021

Inflammasomes within hyperactive murine dendritic cells stimulate long-lived T cell-mediated anti-tumor immunity

Zhivaki et al.,
Cell Reports,
2020

The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer

Raghavan et al.,
bioRxiv,
2020

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

Rozenblatt-Rosen et al.,
Cell,
2020

Spatially-resolved live cell tagging and isolation using protected photoactivatable cell dyes

Genshaft et al.,
bioRxiv,
2020

Mechanisms of lymphoma clearance induced by high-dose alkylating agents

Lossos et al.,
Cancer Discovery,
2019

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

van Galen et al.,
Cell,
2019

Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer

Hamza B. et al.,
PNAS,
2019

Linking single-cell measurements of mass, growth rate, and gene expression

Kimmerling R.J. et al.,
Genome Biology,
2018

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

Jerby-Arnon et al.,
Cell,
2018

Single-cell analyses to tailor treatments

Shalek A.K. et al.,
Science Translational Medicine,
2017

IFNγ-Dependent Tissue-Immune Homeostasis is Co-opted in the Tumor Microenvironment

Nirschl et al.,
Cell,
2017

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Tirosh et al.,
Science,
2016

Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL

Wang et al.,
Blood,
2014

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

Patel et al.,
Science,
2014

Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

Suvà et al.,
Cell,
2014

Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer

Lohr et al.,
Nature Biotechnology,
2014

Nanowire-Mediated Delivery Enables Functional Interrogation of Primary Immune Cells: Application to the Analysis of Chronic Lymphocytic Leukemia

Shalek et al.,
Nano Letters,
2012

Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment

Glycan-costumed virus-like particles promote type 1 anti-tumor immunity

Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation

PI3Kβ controls immune evasion in PTEN-deficient breast tumours

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Compressed phenotypic screens for complex multicellular models and high-content assays

Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity

Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells

Single-Cell Multiomics Reveals Clonal T-Cell Expansions and Exhaustion in Blastic Plasmacytoid Dendritic Cell Neoplasm

PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment

Deciphering the immunopeptidome in vivo reveals new tumour antigens

Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice

Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases

Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

Inflammasomes within hyperactive murine dendritic cells stimulate long-lived T cell-mediated anti-tumor immunity

The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

Spatially-resolved live cell tagging and isolation using protected photoactivatable cell dyes

Mechanisms of lymphoma clearance induced by high-dose alkylating agents

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer

Linking single-cell measurements of mass, growth rate, and gene expression

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

Single-cell analyses to tailor treatments

IFNγ-Dependent Tissue-Immune Homeostasis is Co-opted in the Tumor Microenvironment

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer

Nanowire-Mediated Delivery Enables Functional Interrogation of Primary Immune Cells: Application to the Analysis of Chronic Lymphocytic Leukemia

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