Regulation of X-linked gene expression during early mouse development by Rlim
Biology
Genomics
Alex K. Shalek
Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction
Biology
ChemistryGenomics
R&D
Technology
Alex Genshaft
Jay Prakadan
Carly ZieglerAlex K. Shalek
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
Biology
CancerGenomics
MedicineJay Prakadan
Marc Wadsworth IIAlex Genshaft
Travis HughesCarly Ziegler
Sam Kazer
Aleth Gaillard
Kellie KolbAlex K. Shalek
Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM
ChemistryGenomicsTechnologySam KazerAleth GaillardAlex K. Shalek
Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression
BiologyGenomics
Immunology
Infectious DiseaseSam KazerAlex K. Shalek
A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages
BiologyGenomicsImmunologyR&DTechnologyAlex GenshaftSam KazerAlex K. Shalek
Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity
BiologyGenomicsImmunologyAlex K. Shalek
Oct1 and OCA-B are selectively required for CD4 memory T cell function
BiologyGenomicsImmunologyAlex K. Shalek
Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses
BiologyGenomicsImmunologyInfectious Disease
MicrobiologyTechnologyAlex K. Shalek
Marrying microfluidics and microwells for parallel, high-throughput single-cell genomics
GenomicsR&DTechnologyMarc Wadsworth IITravis HughesAlex K. Shalek
Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
GenomicsR&DTechnologyAlex K. Shalek
Deconstructing transcriptional heterogeneity in pluripotent stem cells
BiologyGenomicsAlex K. Shalek
Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL
CancerGenomicsAlex K. Shalek
Single-cell RNA-seq reveals dynamic paracrine control of cellular variation
BiologyGenomicsAlex K. Shalek
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
CancerGenomicsAlex K. Shalek
Heterogeneity in immune responses: from populations to single cells
GenomicsImmunologyTechnologyAlex K. Shalek
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
BiologyCancerGenomicsAlex K. Shalek
Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer
BiologyCancerGenomicsAlex K. Shalek
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
BiologyGenomicsImmunologyAlex K. Shalek
Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells
BiologyGenomicsAlex K. Shalek
Dynamic regulatory network controlling TH17 cell differentiation
BiologyGenomicsImmunologyAlex K. Shalek
Probing Enzymatic Activity inside Living Cells Using a Nanowire−Cell “Sandwich” Assay
BiologyChemistryImmunologyTechnologyAlex K. Shalek
Nanowire-Mediated Delivery Enables Functional Interrogation of Primary Immune Cells: Application to the Analysis of Chronic Lymphocytic Leukemia
CancerGenomicsR&DTechnologyAlex K. Shalek
Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits
GenomicsImmunologyInfectious DiseaseAlex K. Shalek
Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells
ChemistryGenomics
PhysicsR&DTechnologyAlex K. Shalek