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Genomics
Regulation of X-linked gene expression during early mouse development by Rlim
Wang et al.,
eLife,
2016
Biology
Genomics
Alex K. Shalek
Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction
Genshaft et al.,
Genome Biology,
Biology
Chemistry
Genomics
R&D
Technology
Alex Genshaft
Jay Prakadan
Carly Ziegler
Alex K. Shalek
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
Tirosh et al.,
Science,
2016
Biology
Cancer
Genomics
Medicine
Jay Prakadan
Marc Wadsworth II
Alex Genshaft
Travis Hughes
Carly Ziegler
Sam Kazer
Aleth Gaillard
Kellie Kolb
Alex K. Shalek
Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM
Wong et al.,
PNAS,
2016
Chemistry
Genomics
Technology
Sam Kazer
Aleth Gaillard
Alex K. Shalek
Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression
Kløverpris et al.,
Immunity,
2016
Biology
Genomics
Immunology
Infectious Disease
Sam Kazer
Alex K. Shalek
A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages
Kimmerling et al.,
Nat. Commun.,
2016
Biology
Genomics
Immunology
R&D
Technology
Alex Genshaft
Sam Kazer
Alex K. Shalek
Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity
Gaublomme et al.,
Cell,
2015
Biology
Genomics
Immunology
Alex K. Shalek
Oct1 and OCA-B are selectively required for CD4 memory T cell function
Shakya et al.,
J. Exp. Med.,
2015
Biology
Genomics
Immunology
Alex K. Shalek
Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses
Avraham et al.,
Cell,
2015
Biology
Genomics
Immunology
Infectious Disease
Microbiology
Technology
Alex K. Shalek
Marrying microfluidics and microwells for parallel, high-throughput single-cell genomics
Wadsworth II et al.,
Genome Biology,
2015
Genomics
R&D
Technology
Marc Wadsworth II
Travis Hughes
Alex K. Shalek
Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
Macosko et al.,
Cell,
2015
Genomics
R&D
Technology
Alex K. Shalek
Deconstructing transcriptional heterogeneity in pluripotent stem cells
Kumar et al.,
Nature,
2014
Biology
Genomics
Alex K. Shalek
Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL
Wang et al.,
Blood,
2014
Cancer
Genomics
Alex K. Shalek
Single-cell RNA-seq reveals dynamic paracrine control of cellular variation
Shalek et al.,
Nature,
2014
Biology
Genomics
Alex K. Shalek
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Patel et al.,
Science,
2014
Cancer
Genomics
Alex K. Shalek
Heterogeneity in immune responses: from populations to single cells
Satija et al.,
Trends in Immunology,
2014
Genomics
Immunology
Technology
Alex K. Shalek
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
Suvà et al.,
Cell,
2014
Biology
Cancer
Genomics
Alex K. Shalek
Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer
Lohr et al.,
Nature Biotechnology,
2014
Biology
Cancer
Genomics
Alex K. Shalek
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
Shalek et al.,
Nature,
2013
Biology
Genomics
Immunology
Alex K. Shalek
Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells
Gifford et al.,
Cell,
2013
Biology
Genomics
Alex K. Shalek
Dynamic regulatory network controlling T
H
17 cell differentiation
Yosef et al.,
Nature,
2013
Biology
Genomics
Immunology
Alex K. Shalek
Probing Enzymatic Activity inside Living Cells Using a Nanowire−Cell “Sandwich” Assay
Na et al.,
Nano Letters,
2013
Biology
Chemistry
Immunology
Technology
Alex K. Shalek
Nanowire-Mediated Delivery Enables Functional Interrogation of Primary Immune Cells: Application to the Analysis of Chronic Lymphocytic Leukemia
Shalek et al.,
Nano Letters,
2012
Cancer
Genomics
R&D
Technology
Alex K. Shalek
Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits
Chevrier et al.,
Cell,
2011
Genomics
Immunology
Infectious Disease
Alex K. Shalek
Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells
Shalek et al.,
PNAS,
2010
Chemistry
Genomics
Physics
R&D
Technology
Alex K. Shalek
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