Technology Development Archives

CellLENS enables cross-domain information fusion for enhanced cell population delineation in single-cell spatial omics data

Zhu et al.,
Nature Immunology,
2025

Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients

Genshaft et al.,
Hepatology,
2023

Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation

Bhagchandani et al.,
Science Advances,
2023

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Crouchet et al.,
Nature Communications,
2023

Vitrification preserves murine ovarian follicular cell transcriptome in a 3D encapsulated in vitro follicle growth system

Wang et al.,
Biology of Reproduction,
2023

Compressed phenotypic screens for complex multicellular models and high-content assays

Mead et al.,
bioRxiv,
2023

Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation

Mead et al.,
Nature Biomedical Engineering,
2022

Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity

Genshaft et al.,
bioRxiv,
2021

Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip

Bein et al.,
Frontiers in Pharmacology,
2021

Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice

Hamza et al.,
Nature Communications,
2021

Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes

Genshaft et al.,
Nature Communications,
2021

Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies

Hughes et al.,
Immunity,
2020

High-throughput organoid screening enables engineering of intestinal epithelial composition

Mead et al.,
bioRxiv,
2020

Systematic comparison of single-cell and single-nucleus RNA-sequencing methods

Ding et al.,
Nature Biotechnology,
2020

Spatially-resolved live cell tagging and isolation using protected photoactivatable cell dyes

Genshaft et al.,
bioRxiv,
2020

TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures

Tu et al.,
Nature Immunology,
2019

Voices in methods development

Anikeeva et al.,
Nature Methods,
2019

Highly efficient, massively-parallel single-cell RNA-Seq reveals cellular states and molecular features of human skin pathology

Hughes T.K. et al.,
bioRxiv,
2019

Seq-Well: A Sample-Efficient, Portable Picowell Platform for Massively Parallel Single-Cell RNA Sequencing

Aicher et al.,
Single-Cell Methods,
2019

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

van Galen et al.,
Cell,
2019

Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer

Hamza B. et al.,
PNAS,
2019

Linking single-cell measurements of mass, growth rate, and gene expression

Kimmerling R.J. et al.,
Genome Biology,
2018

Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types

Mead B.E.* et al.,
BMC Biology,
2018

Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices

Prakadan et al.,
Nature Reviews Genetics,
2017

Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput

Gierahn et al.,
Nature Methods,
2017

Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction

Genshaft et al.,
Genome Biology,
2016

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM

Wong et al.,
PNAS,
2016

A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages

Kimmerling et al.,
Nature Communications,
2016

Marrying microfluidics and microwells for parallel, high-throughput single-cell genomics

Wadsworth II et al.,
Genome Biology,
2015

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

Macosko et al.,
Cell,
2015

Preparation of Single-Cell RNA-Seq Libraries for Next Generation Sequencing

Trombetta et al.,
Current Protocols in Molecular Biology,
2014

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

Shalek et al.,
Nature,
2013

Probing Enzymatic Activity inside Living Cells Using a Nanowire−Cell “Sandwich” Assay

Na et al.,
Nano Letters,
2013

Nanowire-Mediated Delivery Enables Functional Interrogation of Primary Immune Cells: Application to the Analysis of Chronic Lymphocytic Leukemia

Shalek et al.,
Nano Letters,
2012

Vertical nanowire electrode arrays as a scalable platform for intracellular interfacing to neuronal circuits

Robinson et al.,
Nature Nanotechnology,
2012

Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells

Shalek et al.,
PNAS,
2010

Photoinduced Interfacial Charging and “Explosion” of Monolayer Pentacene Islands

Chen L. et al.,
Nano Lett,
2005

CellLENS enables cross-domain information fusion for enhanced cell population delineation in single-cell spatial omics data

Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients

Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery

Vitrification preserves murine ovarian follicular cell transcriptome in a 3D encapsulated in vitro follicle growth system

Compressed phenotypic screens for complex multicellular models and high-content assays

Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation

Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity

Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip

Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice

Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes

Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies

High-throughput organoid screening enables engineering of intestinal epithelial composition

Systematic comparison of single-cell and single-nucleus RNA-sequencing methods

Spatially-resolved live cell tagging and isolation using protected photoactivatable cell dyes

TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures

Voices in methods development

Highly efficient, massively-parallel single-cell RNA-Seq reveals cellular states and molecular features of human skin pathology

Seq-Well: A Sample-Efficient, Portable Picowell Platform for Massively Parallel Single-Cell RNA Sequencing

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer

Linking single-cell measurements of mass, growth rate, and gene expression

Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types

Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices

Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput

Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM

A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages

Marrying microfluidics and microwells for parallel, high-throughput single-cell genomics

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

Preparation of Single-Cell RNA-Seq Libraries for Next Generation Sequencing

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

Probing Enzymatic Activity inside Living Cells Using a Nanowire−Cell “Sandwich” Assay

Nanowire-Mediated Delivery Enables Functional Interrogation of Primary Immune Cells: Application to the Analysis of Chronic Lymphocytic Leukemia

Vertical nanowire electrode arrays as a scalable platform for intracellular interfacing to neuronal circuits

Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells

Photoinduced Interfacial Charging and “Explosion” of Monolayer Pentacene Islands

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