Biography

Ben is a postdoc in the Shalek Lab interested in applying single-cell genomics to improve cellular models of human disease and identify new drug targets and therapeutics. Ben’s research harnesses adult stem cell-derived organoids, particularly from the gastrointestinal tract to advance these next-generation cell models, and has focused on applying these models to inflammatory bowel disease.

Ben spent the first ~22 years of his life in and around Boulder, Colorado, including undergrad in Chemical & Biological Engineering at the University of Colorado Boulder. Deciding that 300+ days of sunshine and a culture of ‘work-life balance’ just wasn’t for him, he moved to Boston and embarked on PhD studies with Jeff Karp (Brigham & Women’s Hospital, Harvard Medical School) and Robert Langer (MIT) through the Harvard-MIT Health Sciences & Technology Program. In addition to research, Ben has a persistent entrepreneurial ‘itch’, including stints with the life sciences venture creation firm, Flagship Pioneering, and the Karp & Langer-founded biotech Frequency Therapeutics. When he’s not thinking about science or startups, Ben enjoys spending time with wife, traveling, and taking in the great outdoors.

High-throughput organoid screening enables engineering of intestinal epithelial composition
  • Mead et al.,
  • bioRxiv,
  • 2020
  • R&D
  • Technology
  • Genomics
  • Medicine
  • Biology
  • Ben Mead
  • Marko Vukovic
  • José Ordovas-Montañes
  • Alex K. Shalek
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
  • Ziegler et al.,
  • Cell,
  • 2020
  • Genomics
  • Cell Atlas
  • Infectious Disease
  • Immunology
  • Statistics
  • Biology
  • Carly Ziegler
  • Sam Allon
  • Sarah Nyquist
  • Vincent Miao
  • Constantine Tzouanas
  • Marc Wadsworth II
  • Sam Kazer
  • Travis Hughes
  • Benjamin Doran
  • James Gatter
  • Marko Vukovic
  • Ben Mead
  • Shaina Carroll
  • Alex K. Shalek
  • José Ordovas-Montañes
Spatially-resolved live cell tagging and isolation using protected photoactivatable cell dyes
  • Genshaft et al.,
  • bioRxiv,
  • 2020
  • Genomics
  • Chemistry
  • R&D
  • Cancer
  • Biology
  • Technology
  • Alex Genshaft
  • Carly Ziegler
  • Constantine Tzouanas
  • Ben Mead
  • Andrew Navia
  • Alex K. Shalek
Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression
  • Tsankov et al.,
  • Development,
  • 2019
  • Genomics
  • Biology
  • Marc Wadsworth II
  • Sam Allon
  • Ben Mead
  • Riley Drake
  • Alex K. Shalek
Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types
  • Mead B.E.* et al.,
  • BMC Biology,
  • 2018
  • Ben Mead
  • José Ordovas-Montañes
  • Travis Hughes
  • Marc Wadsworth II
  • Alex K. Shalek