Constantine Tzouanas

Constantine Tzouanas

Graduate Student

Degrees & Affiliations

BS, Bioengineering - Rice University PhD Student, Medical Engineering & Medical Physics - Harvard-MIT Health Sciences & Technology

Background & Interests

Biology Biology
Getting Swole Getting Swole
Keeping the Lab Humble Keeping the Lab Humble
R&D R&D
Technology Technology

Biography

Constantine Tzouanas is a Hertz Fellow and NSF Graduate Research Fellow in the Harvard-MIT Health Sciences and Technology program, pursuing a PhD in Medical Engineering and Medical Physics with a concentration in Biological Engineering.

In the Shalek lab, he researches how the properties and interactions of individual cells produce the emergent phenomena needed for tissue/organism-level function, but go awry in disease states. His work combines technology development, bioinformatics, and wet lab experimentation to bring hard engineering rigor to the squishy world of biology.

As an undergraduate at Rice University, he majored in Bioengineering and minored in Neuroscience. He received the Goldwater Scholarship and worked on circuit neuroscience in the lab of Prof. Jacob Robinson, developing microfluidic devices to uncover principles of neural plasticity in the immortal jellyfish Hydra vulgaris.

Outside of research and coursework at MIT and Harvard, Constantine serves as an officer of the MIT Biotech Group and in the Harvard-MIT Health Sciences and Technology Joint Council. In his free time, Constantine enjoys running, ultimate frisbee, and baking. As mildly interesting trivia facts, his current favorite upbeat indie band is Saint Motel, and his childhood dream job was to become a skyscraper architect.

Publications

Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis
Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis
  • Corleis et al.,
  • Science Translational Medicine,
  • 2023
Computational Methods Computational Methods
Infectious Disease Infectious Disease
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Constantine Tzouanas Constantine Tzouanas
Marc Wadsworth II Marc Wadsworth II
Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival
Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival
  • Tzouanas et al.,
  • bioRxiv,
  • 2023
Biology Biology
Alex K. Shalek Alex K. Shalek
Ben Mead Ben Mead
Constantine Tzouanas Constantine Tzouanas
Evelyn Yuzhou Tong Evelyn Yuzhou Tong
Jay Prakadan Jay Prakadan
Kellie Kolb Kellie Kolb
Michelle Ramseier Michelle Ramseier
Tyler Dao Tyler Dao
Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients
Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients
  • Genshaft et al.,
  • Hepatology,
  • 2023
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
R&D R&D
Technology Technology
Alex Genshaft Alex Genshaft
Alex K. Shalek Alex K. Shalek
Constantine Tzouanas Constantine Tzouanas
Ira Fleming Ira Fleming
Jasmin Joseph-Chazan Jasmin Joseph-Chazan
Mike Vilme Mike Vilme
Nancy Tran Nancy Tran
Riley Drake Riley Drake
Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
  • Gideon et al.,
  • Immunity,
  • 2022
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Conner Kummerlowe Conner Kummerlowe
Constantine Tzouanas Constantine Tzouanas
José Ordovas-Montañes José Ordovas-Montañes
Marc Wadsworth II Marc Wadsworth II
Samira Ibrahim Samira Ibrahim
Sarah Nyquist Sarah Nyquist
Travis Hughes Travis Hughes
Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity
Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity
  • Genshaft et al.,
  • bioRxiv,
  • 2021
Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
R&D R&D
Technology Technology
Alex Genshaft Alex Genshaft
Alex K. Shalek Alex K. Shalek
Constantine Tzouanas Constantine Tzouanas
Ira Fleming Ira Fleming
Jasmin Joseph-Chazan Jasmin Joseph-Chazan
Mike Vilme Mike Vilme
Nancy Tran Nancy Tran
Riley Drake Riley Drake
Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes
Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes
  • Genshaft et al.,
  • Nature Communications,
  • 2021
Genomics Genomics
R&D R&D
Technology Technology
Alex Genshaft Alex Genshaft
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Ben Mead Ben Mead
Carly Ziegler Carly Ziegler
Constantine Tzouanas Constantine Tzouanas
High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
  • Mana et al.,
  • Cell Reports,
  • 2021
Biology Biology
Genomics Genomics
Alex K. Shalek Alex K. Shalek
Constantine Tzouanas Constantine Tzouanas
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
  • Ziegler et al.,
  • Cell,
  • 2020
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Statistics Statistics
Ben Mead Ben Mead
Benjamin Doran Benjamin Doran
Carly Ziegler Carly Ziegler
Constantine Tzouanas Constantine Tzouanas
James Gatter James Gatter
Marc Wadsworth II Marc Wadsworth II
Marko Vukovic Marko Vukovic
Sam Allon Sam Allon
Sarah Nyquist Sarah Nyquist
Vincent Miao Vincent Miao
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is enriched in specific cell subsets across tissues
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is enriched in specific cell subsets across tissues
  • Ziegler et al.,
  • SSRN,
  • 2020
Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Medicine Medicine
Benjamin Doran Benjamin Doran
Carly Ziegler Carly Ziegler
Constantine Tzouanas Constantine Tzouanas
James Gatter James Gatter
Marc Wadsworth II Marc Wadsworth II
Marko Vukovic Marko Vukovic
Sam Allon Sam Allon
Sarah Nyquist Sarah Nyquist
Shaina Carroll Shaina Carroll
Vincent Miao Vincent Miao
Spatially-resolved live cell tagging and isolation using protected photoactivatable cell dyes
Spatially-resolved live cell tagging and isolation using protected photoactivatable cell dyes
  • Genshaft et al.,
  • bioRxiv,
  • 2020
Biology Biology
Cancer Cancer
Chemistry Chemistry
Genomics Genomics
R&D R&D
Technology Technology
Alex Genshaft Alex Genshaft
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Ben Mead Ben Mead
Carly Ziegler Carly Ziegler
Constantine Tzouanas Constantine Tzouanas