Biography

Alex S. Genshaft is a 5th year graduate candidate in the Shalek Lab interested in how communication between cells leads to changes systems-level behaviors. His research focuses on developing tools to probe the intra- and intercellular circuits that drive emergent phenotypes.

 

Alex grew up in Brooklyn, NY where he learned life’s most important facts like who makes the best pizza slice and how to ride the subway. After 18 years in the best city in the world, he moved to Philadelphia, PA to attend the University of Pennsylvania as a Vagelos Scholar in Molecular Life Sciences. There, he worked with Professor David W. Christianson studying terpene synthases and protein structure. He later graduated with B.A.s in Chemistry, Physics, and Biophysics and a M.S. in Chemistry. After college, he moved to Cambridge, MA to enroll in a Ph.D. program at the Department of Chemistry at MIT and work with Alex Shalek.

Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients
  • Genshaft et al.,
  • Hepatology,
  • 2023
  • Technology
  • Immunology
  • R&D
  • Biology
  • Cell Atlas
  • Genomics
  • Alex Genshaft
  • Mike Vilme
  • Riley Drake
  • Ira Fleming
  • Nancy Tran
  • Constantine Tzouanas
  • Jasmin Joseph-Chazan
  • Alex K. Shalek
Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity
  • Genshaft et al.,
  • bioRxiv,
  • 2021
  • Computational Methods
  • Biology
  • Genomics
  • Technology
  • R&D
  • Immunology
  • Cell Atlas
  • Infectious Disease
  • Alex Genshaft
  • Mike Vilme
  • Riley Drake
  • Ira Fleming
  • Nancy Tran
  • Constantine Tzouanas
  • Jasmin Joseph-Chazan
  • Alex K. Shalek
Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes
  • Genshaft et al.,
  • Nature Communications,
  • 2021
  • Technology
  • R&D
  • Genomics
  • Alex Genshaft
  • Carly Ziegler
  • Constantine Tzouanas
  • Ben Mead
  • Andrew Navia
  • Alex K. Shalek
Spatially-resolved live cell tagging and isolation using protected photoactivatable cell dyes
  • Genshaft et al.,
  • bioRxiv,
  • 2020
  • Technology
  • Genomics
  • R&D
  • Chemistry
  • Biology
  • Cancer
  • Alex Genshaft
  • Carly Ziegler
  • Constantine Tzouanas
  • Ben Mead
  • Andrew Navia
  • Alex K. Shalek
Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction
  • Genshaft et al.,
  • Genome Biology,
  • 2016
  • Technology
  • Genomics
  • R&D
  • Chemistry
  • Biology
  • Alex Genshaft
  • Jay Prakadan
  • Carly Ziegler
  • Alex K. Shalek
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
  • Tirosh et al.,
  • Science,
  • 2016
  • Genomics
  • Medicine
  • Cancer
  • Biology
  • Jay Prakadan
  • Marc Wadsworth II
  • Alex Genshaft
  • Travis Hughes
  • Carly Ziegler
  • Sam Kazer
  • Aleth Gaillard
  • Kellie Kolb
  • Alex K. Shalek
A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages
  • Kimmerling et al.,
  • Nat. Commun.,
  • 2016
  • Biology
  • Genomics
  • Immunology
  • R&D
  • Technology
  • Alex Genshaft
  • Sam Kazer
  • Alex K. Shalek