Biography

Ira Fleming is a research technician in the Shalek lab working on producing and analyzing RNA-sequencing data as a lens for the study of infectious disease. He received his B.A. in Molecular Biology from Pomona College in 2018 and moved Eastward, away from SoCal and his home in Seattle. Ira also loves to run, hike, and play music that he composes based on gene sequences on his cello.

Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients

• Genshaft et al.,
• Hepatology,
• 2023

• Technology
• R&D
• Genomics
• Immunology
• Cell Atlas
• Biology
• Alex Genshaft
• Mike Vilme
• Riley Drake
• Ira Fleming
• Nancy Tran
• Constantine Tzouanas
• Jasmin Joseph-Chazan
• Alex K. Shalek

Pro-inflammatory feedback loops define immune responses to pathogenic lentivirus infection

• Wilk et al.,
• bioRxiv,
• 2023

• Immunology
• Infectious Disease
• Genomics
• Sam Kazer
• Ira Fleming
• Vincent Miao
• Jennyfer Galvez-Reyes
• Alex K. Shalek

Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation

• Kummerlowe et al.,
• Science Translational Medicine,
• 2022

• Immunology
• Infectious Disease
• Genomics
• Microbiology
• Biology
• Cell Atlas
• Conner Kummerlowe
• Travis Hughes
• Nolawit Mulugeta
• Ira Fleming
• Marko Vukovic
• Benjamin Doran
• Toby Aicher
• Marc Wadsworth II
• José Ordovas-Montañes
• Alex K. Shalek

Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity

• Genshaft et al.,
• bioRxiv,
• 2021

• Genomics
• Infectious Disease
• Biology
• Immunology
• Computational Methods
• R&D
• Cell Atlas
• Technology
• Alex Genshaft
• Mike Vilme
• Riley Drake
• Ira Fleming
• Nancy Tran
• Constantine Tzouanas
• Jasmin Joseph-Chazan
• Alex K. Shalek

Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells

• Jiang et al.,
• JCI Insight,
• 2021

• Immunology
• Infectious Disease
• Biology
• Genomics
• Ira Fleming
• Alex K. Shalek

Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation in severe disease

• Kummerlowe et al.,
• bioRxiv,
• 2021

• Genomics
• Immunology
• Infectious Disease
• Biology
• Conner Kummerlowe
• Travis Hughes
• Nolawit Mulugeta
• Ira Fleming
• Marko Vukovic
• Benjamin Doran
• José Ordovas-Montañes
• Alex K. Shalek

Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu

• Goods et al.,
• JCI Insight,
• 2021

• Immunology
• Genomics
• Medicine
• Biology
• Brittany Goods
• Riley Drake
• Ira Fleming
• Alex K. Shalek

Functional compensation precedes recovery of tissue mass following acute liver injury

• Walesky et al.,
• Nature Communications,
• 2020

• Immunology
• Biology
• Genomics
• Kellie Kolb
• Ira Fleming
• Alex K. Shalek

Inflammasomes within hyperactive murine dendritic cells stimulate long-lived T cell-mediated anti-tumor immunity

• Zhivaki et al.,
• Cell Reports,
• 2020

• Medicine
• Genomics
• Biology
• Cancer
• Immunology
• Benjamin Doran
• Ira Fleming
• Alex K. Shalek

Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu

• Goods et al.,
• biorXiv,
• 2020

• Genomics
• Immunology
• Biology
• Medicine
• Brittany Goods
• Riley Drake
• Ira Fleming
• Alex K. Shalek