CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection
Abstract
Th1 CD4+ T cells mediate protective antiMtb immunity across biological systemsand organisms. Bromley, Ganchua, et al.demonstrate that CD4+ T cells regulateimmune tone in TB granulomas and arenecessary for immune recall andprotection against reinfection.
Followingreinfection, CD4+ T cells facilitate thedevelopment of a growth restrictive nichevia the induction of immuno-modulatorygenes and cellular interaction networks.