How are methodological developments enabling insights into cell behavior in cellular communities?
Abstract
Our tissues are complex and dynamic multicellular ecosystems. Studies of tissue physiology have helped establish their basic cellular components, and powerful profiling methods have refined lists of cell types/states and their attributes.
Yet, fundamental questions remain as to what influences a cell’s specific role(s) within a tissue and how the collective activity of many cells drives emergent tissue-level functional and dysfunctional behaviors.