NIAID Workshop on T Cell Technologies

  • Biology
  • Cell Atlas
  • Computational Methods
  • Genomics
  • Immunology
  • R&D
  • Alex K. Shalek
  • Gondré-Lewis et al.▾
    Gondré-Lewis, T.A., Jiang, C., Ford, M.L., Koelle, D.M., Sette, A., Shalek, A.K., Thomas, P.G.
  • Nature Immunology , Volume 24 , Issue 1
  • February, 2023
Biology
Cell Atlas
Computational Methods
Genomics
Immunology
R&D
Alex K. Shalek

Abstract

T cells have a central role in adaptive immune responses. However, no accurate assays currently exist that link measurements of ex vivo or in vitro function to effective in vivo T cell responses. Diagnostic detection of T cell function in infectious and immune-mediated diseases also lags in vitro assessments of antibody function. An improved understanding of T cell responses will help researchers and clinicians better predict immune outcomes in response to vaccines, pathogenic infections or immune-mediated diseases. To address these issues, the National Institute of Allergy and Infectious Diseases (NIAID) convened the ‘T Cell Technologies: Assays, Innovations, Challenges, and Opportunities Workshop’ on 15–16 June 2022. The goals of the workshop were to explore assays and technologic advances that could improve understanding of T cell activation and function in different immune conditions, tissues and infections, and to identify methodologies that best provide an accurate measure of T cell biological relevance.

NIAID Workshop on T Cell Technologies