Science Forum: The Human Cell Atlas

Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Medicine Medicine
Technology Technology
Alex K. Shalek Alex K. Shalek

Regev A. et al.▾ Regev A., Teichmann S.A., Lander E.S., Amit I., Benoist C., Birney E., Bodenmiller B., Campbell P.J., Carninci P., Clatworthy M., Clevers H., Deplancke B., Dunham I., Eberwine J., Eils R., Enard W., Farmer A., Fugger L., Göttgens B., Hacohen N., Haniffa M., Hemberg M., Kim S.K., Klenerman P., Kriegstein A., Lein E., Linnarsson S., Lundberg E., Lundeberg J., Majumder P., Marioni J.C., Merad M., Mhlanga M., Nawijn M., Netea M., Nolan G., Pe'er D., Phillipakis A., Ponting C.P., Quake S.R., Reik W., Rozenblatt-Rosen O., Sanes J.R., Satija R., Schumacher T.N., Shalek A.K., Shapiro E., Sharma P., Shin J.W., Stegle O., Stratton M.R., Stubbington M.J.T., Theis J., Uhlen M., van Oudenaarden A., Wagner A., Watt F.M., Weissman J.S., Wold B.J., Xavier R.J., Yosef N., Human Cell Atlas Meeting Participants

eLife

December, 2017

Abstract

The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.