Ben Mead

Ben Mead

Former Postdoctoral Fellow

Degrees & Affiliations

BS, Chemical & Biological Engineering - University of Colorado Boulder PhD, Medical Engineering & Medical Physics - Harvard-MIT Health Sciences & Technology

Background & Interests

Low Braü Low Braü
Medicine Medicine
Technology Technology
Too Many Cooks Too Many Cooks

Biography

Ben is a postdoc in the Shalek Lab interested in applying single-cell genomics to improve cellular models of human disease and identify new drug targets and therapeutics. Ben’s research harnesses adult stem cell-derived organoids, particularly from the gastrointestinal tract to advance these next-generation cell models, and has focused on applying these models to inflammatory bowel disease.

Ben spent the first ~22 years of his life in and around Boulder, Colorado, including undergrad in Chemical & Biological Engineering at the University of Colorado Boulder. Deciding that 300+ days of sunshine and a culture of ‘work-life balance’ just wasn’t for him, he moved to Boston and embarked on PhD studies with Jeff Karp (Brigham & Women’s Hospital, Harvard Medical School) and Robert Langer (MIT) through the Harvard-MIT Health Sciences & Technology Program. In addition to research, Ben has a persistent entrepreneurial ‘itch’, including stints with the life sciences venture creation firm, Flagship Pioneering, and the Karp & Langer-founded biotech Frequency Therapeutics. When he’s not thinking about science or startups, Ben enjoys spending time with wife, traveling, and taking in the great outdoors.

Publications

Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival
Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival
  • Tzouanas et al.,
  • bioRxiv,
  • 2023
Biology Biology
Alex K. Shalek Alex K. Shalek
Ben Mead Ben Mead
Constantine Tzouanas Constantine Tzouanas
Evelyn Yuzhou Tong Evelyn Yuzhou Tong
Jay Prakadan Jay Prakadan
Kellie Kolb Kellie Kolb
Michelle Ramseier Michelle Ramseier
Tyler Dao Tyler Dao
Compressed phenotypic screens for complex multicellular models and high-content assays
Compressed phenotypic screens for complex multicellular models and high-content assays
  • Mead et al.,
  • bioRxiv,
  • 2023
Biology Biology
Cancer Cancer
Chemistry Chemistry
Computational Methods Computational Methods
Genomics Genomics
R&D R&D
Statistics Statistics
Technology Technology
Alex K. Shalek Alex K. Shalek
Ben Mead Ben Mead
Conner Kummerlowe Conner Kummerlowe
Ivy Liu Ivy Liu
Peter Winter Peter Winter
Thomas Nok Hin Cheng Thomas Nok Hin Cheng
Walaa Kattan Walaa Kattan
Cellular and transcriptional diversity over the course of human lactation
Cellular and transcriptional diversity over the course of human lactation
  • Nyquist et al.,
  • PNAS,
  • 2022
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Ben Mead Ben Mead
Brittany Goods Brittany Goods
Kellie Kolb Kellie Kolb
Patricia Gao Patricia Gao
Riley Drake Riley Drake
Sarah Nyquist Sarah Nyquist
Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation
Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation
  • Mead et al.,
  • Nature Biomedical Engineering,
  • 2022
Biology Biology
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Medicine Medicine
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Ben Mead Ben Mead
Conner Kummerlowe Conner Kummerlowe
José Ordovas-Montañes José Ordovas-Montañes
Marko Vukovic Marko Vukovic
Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes
Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes
  • Genshaft et al.,
  • Nature Communications,
  • 2021
Genomics Genomics
R&D R&D
Technology Technology
Alex Genshaft Alex Genshaft
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Ben Mead Ben Mead
Carly Ziegler Carly Ziegler
Constantine Tzouanas Constantine Tzouanas
High-throughput organoid screening enables engineering of intestinal epithelial composition
High-throughput organoid screening enables engineering of intestinal epithelial composition
  • Mead et al.,
  • bioRxiv,
  • 2020
Biology Biology
Genomics Genomics
Medicine Medicine
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Ben Mead Ben Mead
José Ordovas-Montañes José Ordovas-Montañes
Marko Vukovic Marko Vukovic
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
  • Ziegler et al.,
  • Cell,
  • 2020
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Statistics Statistics
Ben Mead Ben Mead
Benjamin Doran Benjamin Doran
Carly Ziegler Carly Ziegler
Constantine Tzouanas Constantine Tzouanas
James Gatter James Gatter
Marc Wadsworth II Marc Wadsworth II
Marko Vukovic Marko Vukovic
Sam Allon Sam Allon
Sarah Nyquist Sarah Nyquist
Vincent Miao Vincent Miao
Spatially-resolved live cell tagging and isolation using protected photoactivatable cell dyes
Spatially-resolved live cell tagging and isolation using protected photoactivatable cell dyes
  • Genshaft et al.,
  • bioRxiv,
  • 2020
Biology Biology
Cancer Cancer
Chemistry Chemistry
Genomics Genomics
R&D R&D
Technology Technology
Alex Genshaft Alex Genshaft
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Ben Mead Ben Mead
Carly Ziegler Carly Ziegler
Constantine Tzouanas Constantine Tzouanas
Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression
Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression
  • Tsankov et al.,
  • Development,
  • 2019
Biology Biology
Genomics Genomics
Alex K. Shalek Alex K. Shalek
Ben Mead Ben Mead
Marc Wadsworth II Marc Wadsworth II
Riley Drake Riley Drake
Sam Allon Sam Allon
Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types
Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types
  • Mead B.E.* et al.,
  • BMC Biology,
  • 2018
Alex K. Shalek Alex K. Shalek
Ben Mead Ben Mead
José Ordovas-Montañes José Ordovas-Montañes
Marc Wadsworth II Marc Wadsworth II
Travis Hughes Travis Hughes