Mutation and cell state compatibility is required and targetable in Ph+ acute lymphoblastic leukemia minimal residual disease
Mutation and cell state compatibility is required and targetable in Ph+ acute lymphoblastic leukemia minimal residual disease
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Cancer Cancer
Microbiology Microbiology
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Jennyfer Galvez-Reyes Jennyfer Galvez-Reyes
Michelle Ramseier Michelle Ramseier
Nolawit Mulugeta Nolawit Mulugeta
Peter Winter Peter Winter
Impact of variants and vaccination on nasal immunity across three waves of SARS-CoV-2
Impact of variants and vaccination on nasal immunity across three waves of SARS-CoV-2
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Infectious Disease Infectious Disease
Medicine Medicine
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Carly Ziegler Carly Ziegler
Josh Bromley Josh Bromley
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Kyle Kimler Kyle Kimler
Micayla George Micayla George
Riley Drake Riley Drake
Samira Ibrahim Samira Ibrahim
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Vincent Miao Vincent Miao
Comprehensive multi-site profiling of the malignant pleural mesothelioma micro-environment identifies candidate molecular determinants of histopathologic type
Comprehensive multi-site profiling of the malignant pleural mesothelioma micro-environment identifies candidate molecular determinants of histopathologic type
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Cancer Cancer
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Systematic deconstruction of myeloid cell signaling in tuberculosis granulomas reveals IFN-γ, TGF-β, and time are associated with conserved myeloid diversity
Systematic deconstruction of myeloid cell signaling in tuberculosis granulomas reveals IFN-γ, TGF-β, and time are associated with conserved myeloid diversity
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Single-cell and spatiotemporal profile of ovulation in the mouse ovary
Single-cell and spatiotemporal profile of ovulation in the mouse ovary
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Brittany Goods Brittany Goods
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Intrahepatic plasma cells, but not atypical memoryB cells, associate with clinical phases of chronichepatitis B
Intrahepatic plasma cells, but not atypical memoryB cells, associate with clinical phases of chronichepatitis B
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Immunology Immunology
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B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles
B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles
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Biology Biology
Immunology Immunology
Infectious Disease Infectious Disease
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Cross-domain information fusion for enhanced cell population delineation in single-cell spatial-omics data
Cross-domain information fusion for enhanced cell population delineation in single-cell spatial-omics data
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An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection
An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection
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Infectious Disease Infectious Disease
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Carly Ziegler Carly Ziegler
Josh Bromley Josh Bromley
José Ordovas-Montañes José Ordovas-Montañes
Micayla George Micayla George
Riley Drake Riley Drake
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A knockoff calibration method to avoid over-clustering in single-cell RNA-sequencing
A knockoff calibration method to avoid over-clustering in single-cell RNA-sequencing
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Microbiology Microbiology
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Scalable nonparametric clustering with unified marker gene selection for single-cell RNA-seq data
Scalable nonparametric clustering with unified marker gene selection for single-cell RNA-seq data
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Medicine Medicine
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Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment
Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment
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Biology Biology
Cancer Cancer
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A Spatial Multi-Modal Dissection of Host-Microbiome Interactions within the Colitis Tissue Microenvironment
A Spatial Multi-Modal Dissection of Host-Microbiome Interactions within the Colitis Tissue Microenvironment
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Congenital T cell activation impairs transitional to follicular B cell maturation in humans
Congenital T cell activation impairs transitional to follicular B cell maturation in humans
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Genomics Genomics
Immunology Immunology
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Scalable nonparametric clustering with unified marker gene selection for single-cell RNA-seq data
Scalable nonparametric clustering with unified marker gene selection for single-cell RNA-seq data
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Computational Methods Computational Methods
Genomics Genomics
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Pro-inflammatory feedback loops define immune responses to pathogenic Lentivirus infection
Pro-inflammatory feedback loops define immune responses to pathogenic Lentivirus infection
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Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Medicine Medicine
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Ira Fleming Ira Fleming
Jennyfer Galvez-Reyes Jennyfer Galvez-Reyes
Sam Kazer Sam Kazer
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Glycan-costumed virus-like particles promote type 1 anti-tumor immunity
Glycan-costumed virus-like particles promote type 1 anti-tumor immunity
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Biology Biology
Cancer Cancer
Genomics Genomics
Immunology Immunology
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CD4 + T cells are homeostatic regulators during Mtb reinfection
CD4 + T cells are homeostatic regulators during Mtb reinfection
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Computational Methods Computational Methods
Immunology Immunology
Infectious Disease Infectious Disease
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Josh Bromley Josh Bromley
Sarah Nyquist Sarah Nyquist
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Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis
Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis
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Infectious Disease Infectious Disease
Medicine Medicine
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Marc Wadsworth II Marc Wadsworth II
Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival
Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival
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Michelle Ramseier Michelle Ramseier
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Natural history of Ebola virus disease in rhesus monkeys shows viral variant emergence dynamics and tissue-specific host responses
Natural history of Ebola virus disease in rhesus monkeys shows viral variant emergence dynamics and tissue-specific host responses
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Genomics Genomics
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
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Identification of drug candidates targeting monocyte reprogramming in people living with HIV
Identification of drug candidates targeting monocyte reprogramming in people living with HIV
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Immunology Immunology
Infectious Disease Infectious Disease
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CD8+ lymphocytes are critical for early control of tuberculosis in macaques
CD8+ lymphocytes are critical for early control of tuberculosis in macaques
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Infectious Disease Infectious Disease
Medicine Medicine
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Travis Hughes Travis Hughes
scRNA-Seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with clinical malaria
scRNA-Seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with clinical malaria
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
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Riley Drake Riley Drake
Vincent Miao Vincent Miao
Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients
Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients
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Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
R&D R&D
Technology Technology
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Alex K. Shalek Alex K. Shalek
Constantine Tzouanas Constantine Tzouanas
Ira Fleming Ira Fleming
Jasmin Joseph-Chazan Jasmin Joseph-Chazan
Mike Vilme Mike Vilme
Nancy Tran Nancy Tran
Riley Drake Riley Drake
Comparative analysis of cell–cell communication at single-cell resolution
Comparative analysis of cell–cell communication at single-cell resolution
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Computational Methods Computational Methods
Genomics Genomics
R&D R&D
Statistics Statistics
Alex K. Shalek Alex K. Shalek
Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation
Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation
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Biology Biology
Cancer Cancer
Chemistry Chemistry
Genomics Genomics
Immunology Immunology
Medicine Medicine
R&D R&D
Technology Technology
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Evelyn Yuzhou Tong Evelyn Yuzhou Tong
Michelle Ramseier Michelle Ramseier
PI3Kβ controls immune evasion in PTEN-deficient breast tumours
PI3Kβ controls immune evasion in PTEN-deficient breast tumours
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Biology Biology
Cancer Cancer
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Jay Prakadan Jay Prakadan
Michelle Ramseier Michelle Ramseier
Pro-inflammatory feedback loops define immune responses to pathogenic lentivirus infection
Pro-inflammatory feedback loops define immune responses to pathogenic lentivirus infection
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Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Ira Fleming Ira Fleming
Jennyfer Galvez-Reyes Jennyfer Galvez-Reyes
Sam Kazer Sam Kazer
Vincent Miao Vincent Miao
A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery
A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery
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Biology Biology
Cancer Cancer
Genomics Genomics
Immunology Immunology
R&D R&D
Technology Technology
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Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease
Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease
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Biology Biology
Genomics Genomics
Immunology Immunology
Medicine Medicine
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José Ordovas-Montañes José Ordovas-Montañes
Marko Vukovic Marko Vukovic
An ex vivo ovulation system enables the discovery of novel ovulatory pathways and nonhormonal contraceptive candidates
An ex vivo ovulation system enables the discovery of novel ovulatory pathways and nonhormonal contraceptive candidates
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Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
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Vitrification preserves murine ovarian follicular cell transcriptome in a 3D encapsulated in vitro follicle growth system
Vitrification preserves murine ovarian follicular cell transcriptome in a 3D encapsulated in vitro follicle growth system
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Biology Biology
Genomics Genomics
Immunology Immunology
R&D R&D
Technology Technology
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Brittany Goods Brittany Goods
Daniela Russo Daniela Russo
Riley Drake Riley Drake
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity
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Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19
Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19
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Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2–Mediated Myocarditis
Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2–Mediated Myocarditis
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Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease
IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease
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Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
Marko Vukovic Marko Vukovic
Compressed phenotypic screens for complex multicellular models and high-content assays
Compressed phenotypic screens for complex multicellular models and high-content assays
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Biology Biology
Cancer Cancer
Chemistry Chemistry
Computational Methods Computational Methods
Genomics Genomics
R&D R&D
Statistics Statistics
Technology Technology
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Ben Mead Ben Mead
Conner Kummerlowe Conner Kummerlowe
Ivy Liu Ivy Liu
Peter Winter Peter Winter
Thomas Nok Hin Cheng Thomas Nok Hin Cheng
Walaa Kattan Walaa Kattan
Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity
Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity
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Cancer Cancer
Genomics Genomics
Immunology Immunology
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
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Peter Winter Peter Winter
NIAID Workshop on T Cell Technologies
NIAID Workshop on T Cell Technologies
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Biology Biology
Cell Atlas Cell Atlas
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Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis)
Identification and characterization of the T cell receptor (TCR) repertoire of the cynomolgus macaque (Macaca Fascicularis)
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Biology Biology
Cell Atlas Cell Atlas
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R&D R&D
Alex K. Shalek Alex K. Shalek
James Gatter James Gatter
Josh Bromley Josh Bromley
Samira Ibrahim Samira Ibrahim
Sarah Nyquist Sarah Nyquist
Tasneem Jivanjee Tasneem Jivanjee
HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control
HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
Sarah Nyquist Sarah Nyquist
Son Nguyen Son Nguyen
Single-cell transcriptomics of staged oocytes and somatic cells reveal novel regulators of follicle activation
Single-cell transcriptomics of staged oocytes and somatic cells reveal novel regulators of follicle activation
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Biology Biology
Genomics Genomics
R&D R&D
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Riley Drake Riley Drake
Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells
Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells
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Biology Biology
Cancer Cancer
Genomics Genomics
Immunology Immunology
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Travis Hughes Travis Hughes
Single-Cell Multiomics Reveals Clonal T-Cell Expansions and Exhaustion in Blastic Plasmacytoid Dendritic Cell Neoplasm
Single-Cell Multiomics Reveals Clonal T-Cell Expansions and Exhaustion in Blastic Plasmacytoid Dendritic Cell Neoplasm
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Biology Biology
Cancer Cancer
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
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Charles P. Couturier Charles P. Couturier
Identification and tracking of alloreactive T cell clones in Rhesus Macaques through the RM-scTCR-Seq platform
Identification and tracking of alloreactive T cell clones in Rhesus Macaques through the RM-scTCR-Seq platform
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Biology Biology
Cell Atlas Cell Atlas
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PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment
PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment
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Biology Biology
Cancer Cancer
Genomics Genomics
Immunology Immunology
Medicine Medicine
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Marc Wadsworth II Marc Wadsworth II
Travis Hughes Travis Hughes
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation
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Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Benjamin Doran Benjamin Doran
Conner Kummerlowe Conner Kummerlowe
Ira Fleming Ira Fleming
José Ordovas-Montañes José Ordovas-Montañes
Marc Wadsworth II Marc Wadsworth II
Marko Vukovic Marko Vukovic
Nolawit Mulugeta Nolawit Mulugeta
Toby Aicher Toby Aicher
Travis Hughes Travis Hughes
Deciphering the immunopeptidome in vivo reveals new tumour antigens
Deciphering the immunopeptidome in vivo reveals new tumour antigens
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Biology Biology
Cancer Cancer
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Peter Winter Peter Winter
How to ensure the Human Cell Atlas benefits humanity
How to ensure the Human Cell Atlas benefits humanity
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Cell Atlas Cell Atlas
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Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
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Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
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Conner Kummerlowe Conner Kummerlowe
Constantine Tzouanas Constantine Tzouanas
José Ordovas-Montañes José Ordovas-Montañes
Marc Wadsworth II Marc Wadsworth II
Samira Ibrahim Samira Ibrahim
Sarah Nyquist Sarah Nyquist
Travis Hughes Travis Hughes
A single-cell liver atlas of Plasmodium vivax infection
A single-cell liver atlas of Plasmodium vivax infection
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Biology Biology
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Immunology Immunology
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Microbiology Microbiology
Technology Technology
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Cellular and transcriptional diversity over the course of human lactation
Cellular and transcriptional diversity over the course of human lactation
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Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Medicine Medicine
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Ben Mead Ben Mead
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Kellie Kolb Kellie Kolb
Patricia Gao Patricia Gao
Riley Drake Riley Drake
Sarah Nyquist Sarah Nyquist
Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation
Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation
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Conner Kummerlowe Conner Kummerlowe
José Ordovas-Montañes José Ordovas-Montañes
Marko Vukovic Marko Vukovic
JAK inhibition in a patient with a STAT1 gain-of-function variant reveals STAT1 dysregulation as a common feature of aplastic anemia
JAK inhibition in a patient with a STAT1 gain-of-function variant reveals STAT1 dysregulation as a common feature of aplastic anemia
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Biology Biology
Genomics Genomics
Immunology Immunology
Medicine Medicine
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Travis Hughes Travis Hughes
Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states
Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states
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Biology Biology
Cancer Cancer
Genomics Genomics
Immunology Immunology
R&D R&D
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Marc Wadsworth II Marc Wadsworth II
Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
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Cancer Cancer
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Genomics Genomics
Immunology Immunology
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Andrew Navia Andrew Navia
Jennyfer Galvez-Reyes Jennyfer Galvez-Reyes
Nolawit Mulugeta Nolawit Mulugeta
Peter Winter Peter Winter
Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity
Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity
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Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
R&D R&D
Technology Technology
Alex Genshaft Alex Genshaft
Alex K. Shalek Alex K. Shalek
Constantine Tzouanas Constantine Tzouanas
Ira Fleming Ira Fleming
Jasmin Joseph-Chazan Jasmin Joseph-Chazan
Mike Vilme Mike Vilme
Nancy Tran Nancy Tran
Riley Drake Riley Drake
Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response
Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
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Carly Ziegler Carly Ziegler
Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2
Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip
Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Medicine Medicine
R&D R&D
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Andrew Navia Andrew Navia
Carly Ziegler Carly Ziegler
José Ordovas-Montañes José Ordovas-Montañes
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Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice
Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice
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Cancer Cancer
Genomics Genomics
Immunology Immunology
Physics Physics
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Single cell biology—a Keystone Symposia report
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Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases
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A Treatment-Naive Cellular Atlas of Pediatric Crohn's Disease Predicts Disease Severity and Therapeutic Response
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Cell Atlas Cell Atlas
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Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients
Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients
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Genomics Genomics
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HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells
HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells
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Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes
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Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
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Expression of Foxp3 by T follicular helper cells in end-stage germinal centers
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The cellular architecture of the antimicrobial response network in human leprosy granulomas
The cellular architecture of the antimicrobial response network in human leprosy granulomas
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Microbiology Microbiology
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Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells
Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells
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Genomics Genomics
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Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells
Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells
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Genomics Genomics
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High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
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Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
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COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
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Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation in severe disease
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MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection
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Microbiology Microbiology
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Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
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Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu
Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu
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How are methodological developments enabling insights into cell behavior in cellular communities?
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Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
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A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2
A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2
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Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
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Genomics Genomics
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Microbiology Microbiology
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Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage
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Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease
Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease
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Single cell profiling of COVID-19 patients: an international data resource from multiple tissues
Single cell profiling of COVID-19 patients: an international data resource from multiple tissues
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Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential
Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential
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Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells
Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells
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The Human Cell Atlas and equity: lessons learned
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Single cell and spatial transcriptomics defines the cellular architecture of the antimicrobial response network in human leprosy granulomas
Single cell and spatial transcriptomics defines the cellular architecture of the antimicrobial response network in human leprosy granulomas
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Functional compensation precedes recovery of tissue mass following acute liver injury
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Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells
Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells
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Biology Biology
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Inflammasomes within hyperactive murine dendritic cells stimulate long-lived T cell-mediated anti-tumor immunity
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Evolution and diversity of immune responses during acute HIV infection
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Medicine Medicine
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Single-cell profiling of ebola virus disease in vivo reveals viral and host dynamics
Single-cell profiling of ebola virus disease in vivo reveals viral and host dynamics
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Single-cell profiling of tuberculosis lung granulomas reveals functional lymphocyte signatures of bacterial control
Single-cell profiling of tuberculosis lung granulomas reveals functional lymphocyte signatures of bacterial control
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Cell Atlas Cell Atlas
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Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies
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Improved haplotype inference by exploiting long-range linking and allelic imbalance in RNA-seq datasets
Improved haplotype inference by exploiting long-range linking and allelic imbalance in RNA-seq datasets
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Innate Lymphoid Cell Activation and Sustained Depletion in Blood and Tissue of Children Infected with HIV from Birth Despite Antiretroviral Therapy
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The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer
The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer
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A Single Human VH-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood
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Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn’s Disease
Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn’s Disease
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Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states
Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states
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Single-cell profiling of Ebola virus infection ​in vivo​ reveals viral and host transcriptional dynamics
Single-cell profiling of Ebola virus infection ​in vivo​ reveals viral and host transcriptional dynamics
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Computational Methods for Single-Cell RNA Sequencing
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High-throughput organoid screening enables engineering of intestinal epithelial composition
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SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
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SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
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Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
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Marc Wadsworth II Marc Wadsworth II
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Single-cell analysis of upper airway cells reveals host-viral dynamics in influenza infected adults
Single-cell analysis of upper airway cells reveals host-viral dynamics in influenza infected adults
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Microbiology Microbiology
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The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution
The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution
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Systematic comparison of single-cell and single-nucleus RNA-sequencing methods
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Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection
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SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is enriched in specific cell subsets across tissues
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Cancer Cancer
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Distribution and storage of inflammatory memory in barrier tissues
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Immunological Fingerprints of Controllers Developing Neutralizing HIV-1 Antibodies
Immunological Fingerprints of Controllers Developing Neutralizing HIV-1 Antibodies
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Identification of a master regulator of differentiation in toxoplasma
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Prevention of tuberculosis in macaques after intravenous BCG immunization
Prevention of tuberculosis in macaques after intravenous BCG immunization
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Medicine Medicine
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Marc Wadsworth II Marc Wadsworth II
Travis Hughes Travis Hughes
TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures
TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures
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Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Revisiting airway epithelial remodeling in type 2 immunity: Beyond goblet cell metaplasia
Revisiting airway epithelial remodeling in type 2 immunity: Beyond goblet cell metaplasia
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Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Sensory neurons innervate peripheral lymph nodes and locally regulate gene expression in postsynaptic endothelium, stromal cells, and innate leukocytes
Sensory neurons innervate peripheral lymph nodes and locally regulate gene expression in postsynaptic endothelium, stromal cells, and innate leukocytes
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Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
José Ordovas-Montañes José Ordovas-Montañes
Marko Vukovic Marko Vukovic
Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration
Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration
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Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Brittany Goods Brittany Goods
Induction of metabolic quiescence defines the transitional to follicular B cell switch
Induction of metabolic quiescence defines the transitional to follicular B cell switch
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Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Toby Aicher Toby Aicher
The next quarter century
The next quarter century
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Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Voices in methods development
Voices in methods development
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Computational Methods Computational Methods
Genomics Genomics
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Germline-encoded affinity for cognate antigen enables vaccine amplification of a human broadly neutralizing response against influenza virus
Germline-encoded affinity for cognate antigen enables vaccine amplification of a human broadly neutralizing response against influenza virus
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression
Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression
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Biology Biology
Genomics Genomics
Alex K. Shalek Alex K. Shalek
Ben Mead Ben Mead
Marc Wadsworth II Marc Wadsworth II
Riley Drake Riley Drake
Sam Allon Sam Allon
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells
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Biology Biology
Cancer Cancer
Genomics Genomics
Medicine Medicine
Alex K. Shalek Alex K. Shalek
A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases
A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases
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Biology Biology
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Intra- and inter-cellular rewiring of the human colon during ulcerative colitis
Intra- and inter-cellular rewiring of the human colon during ulcerative colitis
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Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
Highly efficient, massively-parallel single-cell RNA-Seq reveals cellular states and molecular features of human skin pathology
Highly efficient, massively-parallel single-cell RNA-Seq reveals cellular states and molecular features of human skin pathology
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Biology Biology
Genomics Genomics
Immunology Immunology
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
Marc Wadsworth II Marc Wadsworth II
Travis Hughes Travis Hughes
Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis
Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis
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Biology Biology
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
Identification of a Master Regulator of Differentiation in Toxoplasma
Identification of a Master Regulator of Differentiation in Toxoplasma
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Biology Biology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Marc Wadsworth II Marc Wadsworth II
Integrated Single-Cell Analysis of Multicellular Immune Dynamics during Hyper-Acute HIV-1 Infection
Integrated Single-Cell Analysis of Multicellular Immune Dynamics during Hyper-Acute HIV-1 Infection
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
José Ordovas-Montañes José Ordovas-Montañes
Sam Kazer Sam Kazer
Sarah Nyquist Sarah Nyquist
Shaina Carroll Shaina Carroll
Toby Aicher Toby Aicher
Seq-Well: A Sample-Efficient, Portable Picowell Platform for Massively Parallel Single-Cell RNA Sequencing
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R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Marc Wadsworth II Marc Wadsworth II
Shaina Carroll Shaina Carroll
Toby Aicher Toby Aicher
Travis Hughes Travis Hughes
Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection
Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection
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Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
Mechanisms of lymphoma clearance induced by high-dose alkylating agents
Mechanisms of lymphoma clearance induced by high-dose alkylating agents
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Biology Biology
Cancer Cancer
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Jay Prakadan Jay Prakadan
Kellie Kolb Kellie Kolb
Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration
Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration
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Biology Biology
Cell Atlas Cell Atlas
Medicine Medicine
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity
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Alex K. Shalek Alex K. Shalek
Marc Wadsworth II Marc Wadsworth II
Travis Hughes Travis Hughes
Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer
Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer
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Biology Biology
Cancer Cancer
Computational Methods Computational Methods
R&D R&D
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Alejandro Gupta Alejandro Gupta
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Jay Prakadan Jay Prakadan
Peter Winter Peter Winter
Riley Drake Riley Drake
Linking single-cell measurements of mass, growth rate, and gene expression
Linking single-cell measurements of mass, growth rate, and gene expression
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Biology Biology
Cancer Cancer
Genomics Genomics
Physics Physics
R&D R&D
Technology Technology
Alejandro Gupta Alejandro Gupta
Alex K. Shalek Alex K. Shalek
Jay Prakadan Jay Prakadan
Riley Drake Riley Drake
Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses
Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses
Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation
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Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
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Alex K. Shalek Alex K. Shalek
Rewiring of the cellular and inter-cellular landscape of the human colon during ulcerative colitis
Rewiring of the cellular and inter-cellular landscape of the human colon during ulcerative colitis
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Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
The Human Cell Atlas White Paper
The Human Cell Atlas White Paper
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Alex K. Shalek Alex K. Shalek
High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults
High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults
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Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
Toby Aicher Toby Aicher
Allergic Inflammatory Memory in Human Respiratory Epithelial Progenitor Cells
Allergic Inflammatory Memory in Human Respiratory Epithelial Progenitor Cells
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Biology Biology
Cell Atlas Cell Atlas
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
Marc Wadsworth II Marc Wadsworth II
Marko Vukovic Marko Vukovic
Sam Kazer Sam Kazer
Sarah Nyquist Sarah Nyquist
Travis Hughes Travis Hughes
Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types
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Alex K. Shalek Alex K. Shalek
Ben Mead Ben Mead
José Ordovas-Montañes José Ordovas-Montañes
Marc Wadsworth II Marc Wadsworth II
Travis Hughes Travis Hughes
A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers
A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers
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Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Medicine Medicine
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
Kellie Kolb Kellie Kolb
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells
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Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Science Forum: The Human Cell Atlas
Science Forum: The Human Cell Atlas
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Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Medicine Medicine
Technology Technology
Alex K. Shalek Alex K. Shalek
Reduced cellular diversity and an altered basal progenitor cell state inform epithelial barrier dysfunction in human type 2 immunity
Reduced cellular diversity and an altered basal progenitor cell state inform epithelial barrier dysfunction in human type 2 immunity
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Cell Atlas Cell Atlas
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
Marc Wadsworth II Marc Wadsworth II
Sam Kazer Sam Kazer
Sarah Nyquist Sarah Nyquist
Travis Hughes Travis Hughes
Single-cell analyses to tailor treatments
Single-cell analyses to tailor treatments
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Immunology Immunology
Infectious Disease Infectious Disease
Medicine Medicine
Technology Technology
Alex K. Shalek Alex K. Shalek
Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies
Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies
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Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Medicine Medicine
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
Sam Kazer Sam Kazer
IFNγ-Dependent Tissue-Immune Homeostasis is Co-opted in the Tumor Microenvironment
IFNγ-Dependent Tissue-Immune Homeostasis is Co-opted in the Tumor Microenvironment
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Cancer Cancer
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Jay Prakadan Jay Prakadan
Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices
Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices
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Genomics Genomics
Technology Technology
Alex K. Shalek Alex K. Shalek
Jay Prakadan Jay Prakadan
Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput
Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput
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Chemistry Chemistry
Genomics Genomics
R&D R&D
Technology Technology
Travel Travel
Alex K. Shalek Alex K. Shalek
Marc Wadsworth II Marc Wadsworth II
Travis Hughes Travis Hughes
Circulating CXCR5+CXCR3+PD-1lo Tfh-like Cells in HIV-1 Controllers with Neutralizing Antibody Breadth
Circulating CXCR5+CXCR3+PD-1lo Tfh-like Cells in HIV-1 Controllers with Neutralizing Antibody Breadth
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Biology Biology
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Kellie Kolb Kellie Kolb
Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion
Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion
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Biology Biology
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
Regulation of X-linked gene expression during early mouse development by Rlim
Regulation of X-linked gene expression during early mouse development by Rlim
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Biology Biology
Genomics Genomics
Alex K. Shalek Alex K. Shalek
Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction
Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction
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Biology Biology
Chemistry Chemistry
Genomics Genomics
R&D R&D
Technology Technology
Alex Genshaft Alex Genshaft
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
Jay Prakadan Jay Prakadan
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
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Biology Biology
Cancer Cancer
Genomics Genomics
Medicine Medicine
Aleth Gaillard Aleth Gaillard
Alex Genshaft Alex Genshaft
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
Jay Prakadan Jay Prakadan
Kellie Kolb Kellie Kolb
Marc Wadsworth II Marc Wadsworth II
Sam Kazer Sam Kazer
Travis Hughes Travis Hughes
Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM
Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM
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Chemistry Chemistry
Genomics Genomics
Technology Technology
Aleth Gaillard Aleth Gaillard
Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression
Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages
A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages
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Biology Biology
Genomics Genomics
Immunology Immunology
R&D R&D
Technology Technology
Alex Genshaft Alex Genshaft
Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data
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Computational Methods Computational Methods
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Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity
Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity
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Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Oct1 and OCA-B are selectively required for CD4 memory T cell function
Oct1 and OCA-B are selectively required for CD4 memory T cell function
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Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses
Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Technology Technology
Alex K. Shalek Alex K. Shalek
Marrying microfluidics and microwells for parallel, high-throughput single-cell genomics
Marrying microfluidics and microwells for parallel, high-throughput single-cell genomics
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Genomics Genomics
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Marc Wadsworth II Marc Wadsworth II
Travis Hughes Travis Hughes
Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
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Genomics Genomics
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Deconstructing transcriptional heterogeneity in pluripotent stem cells
Deconstructing transcriptional heterogeneity in pluripotent stem cells
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Biology Biology
Genomics Genomics
Alex K. Shalek Alex K. Shalek
Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL
Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL
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Cancer Cancer
Genomics Genomics
Alex K. Shalek Alex K. Shalek
Preparation of Single-Cell RNA-Seq Libraries for Next Generation Sequencing
Preparation of Single-Cell RNA-Seq Libraries for Next Generation Sequencing
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R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Single-cell RNA-seq reveals dynamic paracrine control of cellular variation
Single-cell RNA-seq reveals dynamic paracrine control of cellular variation
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Biology Biology
Genomics Genomics
Alex K. Shalek Alex K. Shalek
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
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Cancer Cancer
Genomics Genomics
Alex K. Shalek Alex K. Shalek
Heterogeneity in immune responses: from populations to single cells
Heterogeneity in immune responses: from populations to single cells
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Genomics Genomics
Immunology Immunology
Technology Technology
Alex K. Shalek Alex K. Shalek
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
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Biology Biology
Cancer Cancer
Genomics Genomics
Alex K. Shalek Alex K. Shalek
Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer
Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer
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Biology Biology
Cancer Cancer
Genomics Genomics
Alex K. Shalek Alex K. Shalek
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
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Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells
Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells
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Biology Biology
Genomics Genomics
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Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli
Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli
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Biology Biology
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Dynamic regulatory network controlling T<sub>H</sub>17 cell differentiation
Dynamic regulatory network controlling TH17 cell differentiation
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Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Probing Enzymatic Activity inside Living Cells Using a Nanowire−Cell “Sandwich” Assay
Probing Enzymatic Activity inside Living Cells Using a Nanowire−Cell “Sandwich” Assay
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Biology Biology
Chemistry Chemistry
Immunology Immunology
Technology Technology
Alex K. Shalek Alex K. Shalek
Nanowire-Mediated Delivery Enables Functional Interrogation of Primary Immune Cells: Application to the Analysis of Chronic Lymphocytic Leukemia
Nanowire-Mediated Delivery Enables Functional Interrogation of Primary Immune Cells: Application to the Analysis of Chronic Lymphocytic Leukemia
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Cancer Cancer
Genomics Genomics
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Vertical nanowire electrode arrays as a scalable platform for intracellular interfacing to neuronal circuits
Vertical nanowire electrode arrays as a scalable platform for intracellular interfacing to neuronal circuits
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Biology Biology
Chemistry Chemistry
Technology Technology
Alex K. Shalek Alex K. Shalek
Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits
Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits
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Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells
Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells
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Chemistry Chemistry
Genomics Genomics
Physics Physics
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Photoinduced Interfacial Charging and “Explosion” of Monolayer Pentacene Islands
Photoinduced Interfacial Charging and “Explosion” of Monolayer Pentacene Islands
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Chemistry Chemistry
Physics Physics
R&D R&D
Technology Technology
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