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TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures
Tu et al.,
Nature Immunology,
2019
Biology
Cell Atlas
Genomics
Immunology
R&D
Technology
Alex K. Shalek
Revisiting airway epithelial remodeling in type 2 immunity: Beyond goblet cell metaplasia
Barrett et al.,
Journal of Allergy and Clinical Immunology,
2019
Biology
Genomics
Immunology
Alex K. Shalek
Sensory neurons innervate peripheral lymph nodes and locally regulate gene expression in postsynaptic endothelium, stromal cells, and innate leukocytes
Huang et al.,
bioRxiv,
2019
Biology
Cell Atlas
Computational Methods
Genomics
Immunology
Alex K. Shalek
Carly Ziegler
José Ordovas-Montañes
Marko Vukovic
Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration
Menon et al.,
Nature Communications,
2019
Biology
Cell Atlas
Genomics
Immunology
Medicine
Alex K. Shalek
Brittany Goods
Induction of metabolic quiescence defines the transitional to follicular B cell switch
Farmer et al.,
Science Signaling,
2019
Biology
Genomics
Immunology
Alex K. Shalek
Toby Aicher
The next quarter century
Ablasser et al.,
Immunity,
2019
Biology
Genomics
Immunology
Alex K. Shalek
Voices in methods development
Anikeeva et al.,
Nature Methods,
2019
Computational Methods
Genomics
R&D
Technology
Alex K. Shalek
Germline-encoded affinity for cognate antigen enables vaccine amplification of a human broadly neutralizing response against influenza virus
Sangesland et al.,
Immunity,
2019
Biology
Genomics
Immunology
Infectious Disease
Medicine
Alex K. Shalek
Sam Kazer
Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression
Tsankov et al.,
Development,
2019
Biology
Genomics
Alex K. Shalek
Ben Mead
Marc Wadsworth II
Riley Drake
Sam Allon
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells
Reitman et al.,
Nature Communications,
2019
Biology
Cancer
Genomics
Medicine
Alex K. Shalek
A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases
Gawel et al.,
Genome Medicine,
2019
Biology
Computational Methods
Genomics
Immunology
Medicine
Alex K. Shalek
Intra- and inter-cellular rewiring of the human colon during ulcerative colitis
Smillie et al.,
Cell,
2019
Biology
Cell Atlas
Genomics
Immunology
Alex K. Shalek
José Ordovas-Montañes
Highly efficient, massively-parallel single-cell RNA-Seq reveals cellular states and molecular features of human skin pathology
Hughes T.K. et al.,
bioRxiv,
2019
Biology
Genomics
Immunology
R&D
Technology
Alex K. Shalek
José Ordovas-Montañes
Marc Wadsworth II
Travis Hughes
Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis
Ardain A. et al.,
Nature,
2019
Biology
Immunology
Infectious Disease
Alex K. Shalek
Sam Kazer
Identification of a Master Regulator of Differentiation in Toxoplasma
Waldman B.S. et al.,
bioRxiv,
2019
Biology
Infectious Disease
Microbiology
Alex K. Shalek
Marc Wadsworth II
Integrated Single-Cell Analysis of Multicellular Immune Dynamics during Hyper-Acute HIV-1 Infection
Kazer S.W. et al.,
bioRxiv,
2019
Biology
Genomics
Immunology
Infectious Disease
Alex K. Shalek
Carly Ziegler
José Ordovas-Montañes
Sam Kazer
Sarah Nyquist
Shaina Carroll
Toby Aicher
Seq-Well: A Sample-Efficient, Portable Picowell Platform for Massively Parallel Single-Cell RNA Sequencing
Aicher et al.,
Single-Cell Methods,
2019
R&D
Technology
Alex K. Shalek
Marc Wadsworth II
Shaina Carroll
Toby Aicher
Travis Hughes
Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection
Ndhlovu et al.,
Science Translational Medicine,
2019
Genomics
Immunology
Medicine
Alex K. Shalek
Sam Kazer
Mechanisms of lymphoma clearance induced by high-dose alkylating agents
Lossos et al.,
Cancer Discovery,
2019
Biology
Cancer
Immunology
Alex K. Shalek
Jay Prakadan
Kellie Kolb
Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration
Pepe-Mooney et al.,
Cell Stem Cell,
2019
Biology
Cell Atlas
Medicine
Alex K. Shalek
José Ordovas-Montañes
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity
van Galen et al.,
Cell,
2019
Alex K. Shalek
Marc Wadsworth II
Travis Hughes
Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer
Hamza B. et al.,
PNAS,
2019
Biology
Cancer
Computational Methods
R&D
Technology
Alejandro Gupta
Alex K. Shalek
Andrew Navia
Jay Prakadan
Peter Winter
Riley Drake
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