TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures
TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures
  • Tu et al.,
  • Nature Immunology,
  • 2019
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Revisiting airway epithelial remodeling in type 2 immunity: Beyond goblet cell metaplasia
Revisiting airway epithelial remodeling in type 2 immunity: Beyond goblet cell metaplasia
  • Barrett et al.,
  • Journal of Allergy and Clinical Immunology,
  • 2019
Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Sensory neurons innervate peripheral lymph nodes and locally regulate gene expression in postsynaptic endothelium, stromal cells, and innate leukocytes
Sensory neurons innervate peripheral lymph nodes and locally regulate gene expression in postsynaptic endothelium, stromal cells, and innate leukocytes
  • Huang et al.,
  • bioRxiv,
  • 2019
Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
José Ordovas-Montañes José Ordovas-Montañes
Marko Vukovic Marko Vukovic
Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration
Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration
  • Menon et al.,
  • Nature Communications,
  • 2019
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Brittany Goods Brittany Goods
Induction of metabolic quiescence defines the transitional to follicular B cell switch
Induction of metabolic quiescence defines the transitional to follicular B cell switch
  • Farmer et al.,
  • Science Signaling,
  • 2019
Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Toby Aicher Toby Aicher
The next quarter century
The next quarter century
  • Ablasser et al.,
  • Immunity,
  • 2019
Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Voices in methods development
Voices in methods development
  • Anikeeva et al.,
  • Nature Methods,
  • 2019
Computational Methods Computational Methods
Genomics Genomics
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Germline-encoded affinity for cognate antigen enables vaccine amplification of a human broadly neutralizing response against influenza virus
Germline-encoded affinity for cognate antigen enables vaccine amplification of a human broadly neutralizing response against influenza virus
  • Sangesland et al.,
  • Immunity,
  • 2019
Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression
Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression
  • Tsankov et al.,
  • Development,
  • 2019
Biology Biology
Genomics Genomics
Alex K. Shalek Alex K. Shalek
Ben Mead Ben Mead
Marc Wadsworth II Marc Wadsworth II
Riley Drake Riley Drake
Sam Allon Sam Allon
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells
  • Reitman et al.,
  • Nature Communications,
  • 2019
Biology Biology
Cancer Cancer
Genomics Genomics
Medicine Medicine
Alex K. Shalek Alex K. Shalek
A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases
A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases
  • Gawel et al.,
  • Genome Medicine,
  • 2019
Biology Biology
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Intra- and inter-cellular rewiring of the human colon during ulcerative colitis
Intra- and inter-cellular rewiring of the human colon during ulcerative colitis
  • Smillie et al.,
  • Cell,
  • 2019
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
Highly efficient, massively-parallel single-cell RNA-Seq reveals cellular states and molecular features of human skin pathology
Highly efficient, massively-parallel single-cell RNA-Seq reveals cellular states and molecular features of human skin pathology
  • Hughes T.K. et al.,
  • bioRxiv,
  • 2019
Biology Biology
Genomics Genomics
Immunology Immunology
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
Marc Wadsworth II Marc Wadsworth II
Travis Hughes Travis Hughes
Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis
Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis
  • Ardain A. et al.,
  • Nature,
  • 2019
Biology Biology
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
Identification of a Master Regulator of Differentiation in Toxoplasma
Identification of a Master Regulator of Differentiation in Toxoplasma
  • Waldman B.S. et al.,
  • bioRxiv,
  • 2019
Biology Biology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Marc Wadsworth II Marc Wadsworth II
Integrated Single-Cell Analysis of Multicellular Immune Dynamics during Hyper-Acute HIV-1 Infection
Integrated Single-Cell Analysis of Multicellular Immune Dynamics during Hyper-Acute HIV-1 Infection
  • Kazer S.W. et al.,
  • bioRxiv,
  • 2019
Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
José Ordovas-Montañes José Ordovas-Montañes
Sam Kazer Sam Kazer
Sarah Nyquist Sarah Nyquist
Shaina Carroll Shaina Carroll
Toby Aicher Toby Aicher
Seq-Well: A Sample-Efficient, Portable Picowell Platform for Massively Parallel Single-Cell RNA Sequencing
  • Aicher et al.,
  • Single-Cell Methods,
  • 2019
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Marc Wadsworth II Marc Wadsworth II
Shaina Carroll Shaina Carroll
Toby Aicher Toby Aicher
Travis Hughes Travis Hughes
Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection
Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection
  • Ndhlovu et al.,
  • Science Translational Medicine,
  • 2019
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
Mechanisms of lymphoma clearance induced by high-dose alkylating agents
Mechanisms of lymphoma clearance induced by high-dose alkylating agents
  • Lossos et al.,
  • Cancer Discovery,
  • 2019
Biology Biology
Cancer Cancer
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Jay Prakadan Jay Prakadan
Kellie Kolb Kellie Kolb
Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration
Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration
  • Pepe-Mooney et al.,
  • Cell Stem Cell,
  • 2019
Biology Biology
Cell Atlas Cell Atlas
Medicine Medicine
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity
  • van Galen et al.,
  • Cell,
  • 2019
Alex K. Shalek Alex K. Shalek
Marc Wadsworth II Marc Wadsworth II
Travis Hughes Travis Hughes
Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer
Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer
  • Hamza B. et al.,
  • PNAS,
  • 2019
Biology Biology
Cancer Cancer
Computational Methods Computational Methods
R&D R&D
Technology Technology
Alejandro Gupta Alejandro Gupta
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Jay Prakadan Jay Prakadan
Peter Winter Peter Winter
Riley Drake Riley Drake