TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures
Biology
Cell Atlas
Genomics
Immunology
R&D
Technology
Alex K. Shalek
Revisiting airway epithelial remodeling in type 2 immunity: Beyond goblet cell metaplasia
BiologyGenomicsImmunologyAlex K. Shalek
Sensory neurons innervate peripheral lymph nodes and locally regulate gene expression in postsynaptic endothelium, stromal cells, and innate leukocytes
BiologyCell Atlas
Computational MethodsGenomicsImmunology
Carly Ziegler
Marko Vukovic
José Ordovas-MontañesAlex K. Shalek
Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration
BiologyCell AtlasGenomicsImmunology
Medicine
Brittany GoodsAlex K. Shalek
Induction of metabolic quiescence defines the transitional to follicular B cell switch
BiologyGenomicsImmunology
Toby AicherAlex K. Shalek
The next quarter century
BiologyGenomicsImmunologyAlex K. Shalek
Voices in methods development
Computational MethodsGenomicsR&DTechnologyAlex K. Shalek
Germline-encoded affinity for cognate antigen enables vaccine amplification of a human broadly neutralizing response against influenza virus
BiologyGenomicsImmunology
Infectious DiseaseMedicine
Sam KazerAlex K. Shalek
Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression
BiologyGenomics
Marc Wadsworth II
Sam Allon
Ben Mead
Riley DrakeAlex K. Shalek
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells
Biology
CancerGenomicsMedicineAlex K. Shalek
A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases
BiologyComputational MethodsGenomicsImmunologyMedicineAlex K. Shalek
Intra- and inter-cellular rewiring of the human colon during ulcerative colitis
BiologyCell AtlasGenomicsImmunologyJosé Ordovas-MontañesAlex K. Shalek
Highly efficient, massively-parallel single-cell RNA-Seq reveals cellular states and molecular features of human skin pathology
BiologyGenomicsImmunologyR&DTechnology
Travis HughesMarc Wadsworth IIJosé Ordovas-MontañesAlex K. Shalek
Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis
BiologyImmunologyInfectious DiseaseSam KazerAlex K. Shalek
Identification of a Master Regulator of Differentiation in Toxoplasma
BiologyInfectious Disease
MicrobiologyMarc Wadsworth IIAlex K. Shalek
Integrated Single-Cell Analysis of Multicellular Immune Dynamics during Hyper-Acute HIV-1 Infection
BiologyGenomicsImmunologyInfectious DiseaseSam KazerToby Aicher
Shaina CarrollJosé Ordovas-MontañesCarly Ziegler
Sarah NyquistAlex K. ShalekSeq-Well: A Sample-Efficient, Portable Picowell Platform for Massively Parallel Single-Cell RNA Sequencing
R&DTechnologyToby AicherShaina CarrollMarc Wadsworth IITravis HughesAlex K. Shalek
Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection
GenomicsImmunologyMedicineSam KazerAlex K. Shalek
Mechanisms of lymphoma clearance induced by high-dose alkylating agents
BiologyCancerImmunology
Kellie Kolb
Jay PrakadanAlex K. Shalek
Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration
BiologyCell AtlasMedicineJosé Ordovas-MontañesAlex K. Shalek
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity
Marc Wadsworth IITravis HughesAlex K. Shalek
Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer
BiologyCancerComputational MethodsR&DTechnologyJay Prakadan
Andrew Navia
Peter WinterRiley Drake
Alejandro GuptaAlex K. Shalek