2021 - Shalek Lab

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

Raghavan et al.,
Cell,
2021

Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity

Genshaft et al.,
bioRxiv,
2021

Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response

Rodel et al.,
Frontiers in Microbiology,
2021

Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2

Francis et al.,
Science Immunology,
2021

Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip

Bein et al.,
Frontiers in Pharmacology,
2021

Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice

Hamza et al.,
Nature Communications,
2021

Single cell biology—a Keystone Symposia report

Cable et al.,
Annals of the New York Academy of Sciences,
2021

Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases

Prakadan et al.,
Nature Communications,
2021

A Treatment-Naive Cellular Atlas of Pediatric Crohn's Disease Predicts Disease Severity and Therapeutic Response

Zheng et al.,
bioRxiv,
2021

Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients

Youngs et al.,
PLOS Pathogens,
2021

HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells

Fardoos et al.,
JCI Insight,
2021

Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes

Genshaft et al.,
Nature Communications,
2021

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19

Ziegler et al.,
Cell,
2021

Expression of Foxp3 by T follicular helper cells in end-stage germinal centers

Jacobsen et al.,
Science,
2021

The cellular architecture of the antimicrobial response network in human leprosy granulomas

Ma et al.,
Nature Immunology,
2021

Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells

Jiang et al.,
JCI Insight,
2021

High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity

Mana et al.,
Cell Reports,
2021

Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

Amoozgar et al.,
Nature Communications,
2021

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

Delorey et al.,
Nature,
2021

Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation in severe disease

Kummerlowe et al.,
bioRxiv,
2021

MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection

Khuzwayo et al.,
Frontiers in Immunology,
2021

Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation

Dwyer et al.,
Science Immunology,
2021

Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu

Goods et al.,
JCI Insight,
2021

How are methodological developments enabling insights into cell behavior in cellular communities?

Piddini et al.,
Cell Systems,
2021

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

Muus et al.,
Nature Medicine,
2021

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

Delorey et al.,
bioRxiv,
2021

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19

Ziegler et al.,
bioRxiv,
2021

Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage

Askenase et al.,
Science Immunology,
2021

Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease

Tkachev et al.,
Science Translational Medicine,
2021

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