Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
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Cancer Cancer
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Medicine Medicine
R&D R&D
Technology Technology
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Andrew Navia Andrew Navia
Jennyfer Galvez-Reyes Jennyfer Galvez-Reyes
Nolawit Mulugeta Nolawit Mulugeta
Peter Winter Peter Winter
Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity
Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity
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Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
R&D R&D
Technology Technology
Alex Genshaft Alex Genshaft
Alex K. Shalek Alex K. Shalek
Constantine Tzouanas Constantine Tzouanas
Ira Fleming Ira Fleming
Jasmin Joseph-Chazan Jasmin Joseph-Chazan
Mike Vilme Mike Vilme
Nancy Tran Nancy Tran
Riley Drake Riley Drake
Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response
Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2
Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip
Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Medicine Medicine
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Carly Ziegler Carly Ziegler
José Ordovas-Montañes José Ordovas-Montañes
Vincent Miao Vincent Miao
Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice
Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice
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Biology Biology
Cancer Cancer
Genomics Genomics
Immunology Immunology
Physics Physics
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Nolawit Mulugeta Nolawit Mulugeta
Single cell biology—a Keystone Symposia report
Single cell biology—a Keystone Symposia report
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Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Alex K. Shalek Alex K. Shalek
Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases
Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases
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Biology Biology
Cancer Cancer
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Jay Prakadan Jay Prakadan
Kellie Kolb Kellie Kolb
Marc Wadsworth II Marc Wadsworth II
A Treatment-Naive Cellular Atlas of Pediatric Crohn's Disease Predicts Disease Severity and Therapeutic Response
A Treatment-Naive Cellular Atlas of Pediatric Crohn's Disease Predicts Disease Severity and Therapeutic Response
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Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Benjamin Doran Benjamin Doran
José Ordovas-Montañes José Ordovas-Montañes
Kyle Kimler Kyle Kimler
Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients
Identification of immune correlates of fatal outcomes in critically ill COVID-19 patients
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Vincent Miao Vincent Miao
HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells
HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells
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Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Sarah Nyquist Sarah Nyquist
Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes
Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes
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Genomics Genomics
R&D R&D
Technology Technology
Alex Genshaft Alex Genshaft
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Ben Mead Ben Mead
Carly Ziegler Carly Ziegler
Constantine Tzouanas Constantine Tzouanas
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
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Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Carly Ziegler Carly Ziegler
Josh Bromley Josh Bromley
José Ordovas-Montañes José Ordovas-Montañes
Micayla George Micayla George
Riley Drake Riley Drake
Vincent Miao Vincent Miao
Expression of Foxp3 by T follicular helper cells in end-stage germinal centers
Expression of Foxp3 by T follicular helper cells in end-stage germinal centers
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Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Sam Allon Sam Allon
The cellular architecture of the antimicrobial response network in human leprosy granulomas
The cellular architecture of the antimicrobial response network in human leprosy granulomas
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Marc Wadsworth II Marc Wadsworth II
Travis Hughes Travis Hughes
Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells
Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Ira Fleming Ira Fleming
Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells
Single-cell immunophenotyping of the skin lesion erythema migrans identifies IgM memory B cells
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Ira Fleming Ira Fleming
High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
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Biology Biology
Genomics Genomics
Alex K. Shalek Alex K. Shalek
Constantine Tzouanas Constantine Tzouanas
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
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Cancer Cancer
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Sam Kazer Sam Kazer
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
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Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Statistics Statistics
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation in severe disease
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation in severe disease
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Benjamin Doran Benjamin Doran
Conner Kummerlowe Conner Kummerlowe
Ira Fleming Ira Fleming
José Ordovas-Montañes José Ordovas-Montañes
Marko Vukovic Marko Vukovic
Nolawit Mulugeta Nolawit Mulugeta
Travis Hughes Travis Hughes
MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection
MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Jay Prakadan Jay Prakadan
Sam Kazer Sam Kazer
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
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Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
Marko Vukovic Marko Vukovic
Sam Allon Sam Allon
Sarah Nyquist Sarah Nyquist
Travis Hughes Travis Hughes
Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu
Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu
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Biology Biology
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Brittany Goods Brittany Goods
Ira Fleming Ira Fleming
Riley Drake Riley Drake
How are methodological developments enabling insights into cell behavior in cellular communities?
How are methodological developments enabling insights into cell behavior in cellular communities?
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Biology Biology
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
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Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Statistics Statistics
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
Marc Wadsworth II Marc Wadsworth II
Sam Allon Sam Allon
Sarah Nyquist Sarah Nyquist
A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2
A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2
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Biology Biology
Cell Atlas Cell Atlas
Computational Methods Computational Methods
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Statistics Statistics
Alex K. Shalek Alex K. Shalek
Carly Ziegler Carly Ziegler
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
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Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Carly Ziegler Carly Ziegler
Josh Bromley Josh Bromley
José Ordovas-Montañes José Ordovas-Montañes
Micayla George Micayla George
Riley Drake Riley Drake
Vincent Miao Vincent Miao
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage
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Biology Biology
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Brittany Goods Brittany Goods
James Gatter James Gatter
Riley Drake Riley Drake
Shaina Carroll Shaina Carroll
Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease
Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease
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Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Jim Kaminski Jim Kaminski
José Ordovas-Montañes José Ordovas-Montañes