Degrees & Affiliations
BA, Biology - Tufts University PhD, Immunology - Harvard University
Background & Interests







Biography
Jose is a second-year Postdoctoral Fellow in the Shalek lab where he is interested in utilizing single-cell genomics to understand the organizing principles of mucosal barrier tissues in health and how to re-balance them in disease. Jose’s research specifically looks at the human gastrointestinal tract and respiratory airways in inflammatory and allergic states, respectively.
Jose grew up in the Boston area, circling the perimeter with high school in Framingham, MA, college at Tufts University, and graduate studies in the Harvard Immunology program. During his undergraduate, Jose worked in human immunology labs at Biogen Idec, University College London, and Children’s Hospital Boston where he focused on monogenic immune deficiencies. For his PhD work, Jose trained with Uli von Andrian studying how the nervous system and the immune system function together as the principal sensory interfaces between the internal and external environment. Due to his problem of reading too much, realizing that this only covered two broad classes of cells, and wanting to return to the human system, he decided to take the plunge into the field of single cell genomics to be able to work on all cell types all the time. Jose is a recently retired amateur bike racer and a perpetually amateur chef.
Publications

Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2
















Distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense







Impact of variants and vaccination on nasal immunity across three waves of SARS-CoV-2













An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection












Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease








IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease







Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation

















Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control















Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation













Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip











