Kyle Kimler

Former Research Associate

Degrees & Affiliations

BS, Biology - University of Notre Dame MS, Molecular Techniques in Life Sciences - Karolinska Institutet

Background & Interests

Biography

Kyle Kimler was born in Charleston, West Virginia. In his youth he traveled and lived all around the USA and having caught the bug, later explored Asia, Australia, and Europe. At some point he landed in Carlsbad, California where he worked in R&D Cell Bio custom services at Thermo Fisher. Ever feeling the urge to wander, after three years he moved to Stockholm, Sweden when given the opportunity to learn bioinformatics in a MS at SciLifeLab in Sweden. There, he also worked in labs, cloning bio-orthogonal single amino acid tags in Simon Elsaesser’s Lab, building networks of coexpression from spatial transcriptomics in Erik Sonnhammer’s Lab, and developing model chemolithoautotrophic bacteria in Paul Hudson’s Lab.

Kyle joined the Shalek Lab by way of the Ordovas-Montanes Lab. He also collaborates with Leslie Kean, and together with all three labs works on the PREDICT project, aiming to develop precision diagnostics and treatments for inflammatory bowel disease. Kyle’s main research interests are in the limits of understanding we can attain with current biotechnologies. He works primarily with single cell RNA-seq data, searching for computational methods to categorize human cell types and cell states at the highest possible resolution.

Publications

Impact of variants and vaccination on nasal immunity across three waves of SARS-CoV-2

Long et al.,
biorxiv,
2024

A Treatment-Naive Cellular Atlas of Pediatric Crohn's Disease Predicts Disease Severity and Therapeutic Response

Zheng et al.,
bioRxiv,
2021