Travis Hughes

Travis Hughes

Former MD-PhD Student

Degrees & Affiliations

BS, Biology - Oklahoma Christian University MPH, Epidemiology - University of Michigan, Ann Arbor Medical Student - Harvard Medical School (HST) PhD Candidate, Immunology - Harvard Medical School

Background & Interests

Biology Biology
Cancer Cancer
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Making Waves Making Waves
Top Shelf Top Shelf
Travel Travel

Biography

Travis is an MD-PhD student in the Shalek Lab pursuing an MD in HST and a PhD in the Harvard Immunology program. He is broadly interested in developing and applying single-cell technologies to understand cellular ecology in health and disease. Current projects include developing improvements and extensions of the Seq-Well platform, and he is working on a large project aimed to understand the cellular ecology of M. tuberculosis granulomas.

Travis is a native of Oklahoma and did his undergraduate work in Biology at Oklahoma Christian University. During college, he co-founded a non-profit organization called Wishing Well, which raises money for water projects. After graduation, he spent time working on international development projects in Rwanda and Uganda before returning to Oklahoma to begin work in the lab of Amr Sawalha at the Oklahoma Medical Research Foundation. Travis obtained a MPH in Epidemiology and International Health at the University of Michigan, Ann Arbor. Prior to coming to HMS and MIT, he spent an additional year in the lab working on autoimmune genetics, while simultaneously working as a live-in caregiver for a man living with multiple sclerosis. In his spare time, Travis enjoys reading, sailing, amateur mixology, pottery, and analog photography.

 

Publications

Comprehensive multi-site profiling of the malignant pleural mesothelioma micro-environment identifies candidate molecular determinants of histopathologic type
Comprehensive multi-site profiling of the malignant pleural mesothelioma micro-environment identifies candidate molecular determinants of histopathologic type
  • Severson et al.,
  • biorxiv,
  • 2024
Cancer Cancer
Computational Methods Computational Methods
Alex K. Shalek Alex K. Shalek
Travis Hughes Travis Hughes
Systematic deconstruction of myeloid cell signaling in tuberculosis granulomas reveals IFN-γ, TGF-β, and time are associated with conserved myeloid diversity
Systematic deconstruction of myeloid cell signaling in tuberculosis granulomas reveals IFN-γ, TGF-β, and time are associated with conserved myeloid diversity
  • Peters et al.,
  • biorxiv,
  • 2024
Alex K. Shalek Alex K. Shalek
Josh Bromley Josh Bromley
Sarah Nyquist Sarah Nyquist
Travis Hughes Travis Hughes
CD8+ lymphocytes are critical for early control of tuberculosis in macaques
CD8+ lymphocytes are critical for early control of tuberculosis in macaques
  • Winchell et al.,
  • Journal of Experimental Medicine,
  • 2023
Computational Methods Computational Methods
Infectious Disease Infectious Disease
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Josh Bromley Josh Bromley
Marc Wadsworth II Marc Wadsworth II
Sarah Nyquist Sarah Nyquist
Travis Hughes Travis Hughes
Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells
Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells
  • Morris et al.,
  • Cell Reports,
  • 2023
Biology Biology
Cancer Cancer
Genomics Genomics
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Travis Hughes Travis Hughes
PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment
PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment
  • Collins et al.,
  • Journal for Immunotherapy of Cancer,
  • 2023
Biology Biology
Cancer Cancer
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Marc Wadsworth II Marc Wadsworth II
Travis Hughes Travis Hughes
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation
  • Kummerlowe et al.,
  • Science Translational Medicine,
  • 2022
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Benjamin Doran Benjamin Doran
Conner Kummerlowe Conner Kummerlowe
Ira Fleming Ira Fleming
José Ordovas-Montañes José Ordovas-Montañes
Marc Wadsworth II Marc Wadsworth II
Marko Vukovic Marko Vukovic
Nolawit Mulugeta Nolawit Mulugeta
Toby Aicher Toby Aicher
Travis Hughes Travis Hughes
Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
  • Gideon et al.,
  • Immunity,
  • 2022
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Conner Kummerlowe Conner Kummerlowe
Constantine Tzouanas Constantine Tzouanas
José Ordovas-Montañes José Ordovas-Montañes
Marc Wadsworth II Marc Wadsworth II
Samira Ibrahim Samira Ibrahim
Sarah Nyquist Sarah Nyquist
Travis Hughes Travis Hughes
A single-cell liver atlas of Plasmodium vivax infection
A single-cell liver atlas of Plasmodium vivax infection
  • Mancio-Silva et al.,
  • Cell Host & Microbe,
  • 2022
Biology Biology
Cell Atlas Cell Atlas
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Technology Technology
Alex K. Shalek Alex K. Shalek
Marc Wadsworth II Marc Wadsworth II
Travis Hughes Travis Hughes
JAK inhibition in a patient with a STAT1 gain-of-function variant reveals STAT1 dysregulation as a common feature of aplastic anemia
JAK inhibition in a patient with a STAT1 gain-of-function variant reveals STAT1 dysregulation as a common feature of aplastic anemia
  • Rosenberg et al.,
  • Med,
  • 2022
Biology Biology
Genomics Genomics
Immunology Immunology
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Travis Hughes Travis Hughes
The cellular architecture of the antimicrobial response network in human leprosy granulomas
The cellular architecture of the antimicrobial response network in human leprosy granulomas
  • Ma et al.,
  • Nature Immunology,
  • 2021
Biology Biology
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Marc Wadsworth II Marc Wadsworth II
Travis Hughes Travis Hughes