Research in the Shalek Lab is directed towards the creation and implementation of new technologies to understand how cells collectively perform systems-level functions in healthy and diseased states. We employ a comprehensive, five-step approach , developing innovative methodologies and applying them across multiple systems to empower more mechanistic inquiry and a deeper understanding of the rules that govern ensemble cellular behaviors.
We used single-cell RNA-seq to uncover basal cell reprogramming in allergic airway disease.
Seq-Well is a portable and inexpensive platform for high-throughput single-cell RNA sequencing. We report robust single-cell transcriptional profiling on cell lines and primary human cells.
Congratulations to Jay Prakadan for successfully defending his thesis! We wish Jay the best of luck in his future endeavors, and we’re excited for all the upcoming defenses this year!
Our paper on increased tuberculosis (TB) vaccine efficacy with intravenous injection in nonhuman primates is now out in Nature. With collaborators at the National Institutes of Health's National Institute of Allergy and Infectious Diseases and others, we show greatly enhanced immune protection and outcome compared to traditional intradermal injection of…
Carly's data visualization of SHIV infection in rhesus macaques (previously lauded here and here) has been selected as one of the best science images of 2019 by the Nature news team. Read about it here.