Research in the Shalek Lab is directed towards the creation and implementation of new technologies to understand how cells collectively perform systems-level functions in healthy and diseased states. We employ a comprehensive, five-step approach , developing innovative methodologies and applying them across multiple systems to empower more mechanistic inquiry and a deeper understanding of the rules that govern ensemble cellular behaviors.
Our Research
Featured Publications
Allergic Inflammatory Memory in Human Respiratory Epithelial Progenitor Cells
Biology
Cell Atlas
Immunology
Medicine
José Ordovas-Montañes
Sarah Nyquist
Travis Hughes
Marc Wadsworth
Sam Kazer
Alex K. ShalekWe used single-cell RNA-seq to uncover basal cell reprogramming in allergic airway disease.
Seq-Well is a portable and inexpensive platform for high-throughput single-cell RNA sequencing. We report robust single-cell transcriptional profiling on cell lines and primary human cells.
Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput
Chemistry
Genomics
R&D
Technology
TravelMarc WadsworthTravis HughesAlex K. ShalekNews
Our Recent Paper on Allergic Inflammation Featured in JACI
Research in the Shalek Lab is directed towards the creation and implementation of new technologies to understand how cells collectively perform systems-level functions in healthy and diseased states. We employ a comprehensive, five-step approach , developing innovative methodologies and applying...
Our work on inflammatory memory highlighted in Quanta Magazine
Research in the Shalek Lab is directed towards the creation and implementation of new technologies to understand how cells collectively perform systems-level functions in healthy and diseased states. We employ a comprehensive, five-step approach , developing innovative methodologies and applying...
New Paper on Ulcerative Colitis on BioRxiv
Research in the Shalek Lab is directed towards the creation and implementation of new technologies to understand how cells collectively perform systems-level functions in healthy and diseased states. We employ a comprehensive, five-step approach , developing innovative methodologies and applying...