Our Research

Research in the Shalek Lab is directed towards the creation and implementation of new technologies to understand how cells collectively perform systems-level functions in healthy and diseased states. We employ a comprehensive, five-step approach , developing innovative methodologies and applying them across multiple systems to empower more mechanistic inquiry and a deeper understanding of the rules that govern ensemble cellular behaviors.

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Featured Publications

Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput
  • Gierahn et al.,
  • Nature Methods,
  • 2017
Chemistry
Genomics
R&D
Technology
Travel
Marc Wadsworth
Travis Hughes
Alex K. Shalek

Seq-Well is a portable and inexpensive platform for high-throughput single-cell RNA sequencing. We report robust single-cell transcriptional profiling on cell lines and primary human cells.

We applied single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 Melanoma patients, profiling malignant, immune, stromal, and endothelial cells.

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
  • Tirosh et al.,
  • Science,
  • 2016
Biology
Cancer
Genomics
Medicine
Jay Prakadan
Marc Wadsworth
Alex Genshaft
Travis Hughes
Carly Ziegler
Sam Kazer
Aleth Gaillard
Kellie Kolb
Alex K. Shalek

News

Lab Member Awards & Fellowships 2017, Part 1

Research in the Shalek Lab is directed towards the creation and implementation of new technologies to understand how cells collectively perform systems-level functions in healthy and diseased states. We employ a comprehensive, five-step approach , developing innovative methodologies and applying...

Alex Shalek named Pfizer-Laubach Career Development Professor

Alex Shalek has been appointed to the Pfizer-Laubach Career Development Professorship at MIT. The Pfizer-Laubach Chair was established by Pfizer to honor Dr. Gerald D. Laubach, MIT alumnus and former president of Pfizer Inc. Congratulations, Alex!...