Our Research

Research in the Shalek Lab is directed towards the creation and implementation of new technologies to understand how cells collectively perform systems-level functions in healthy and diseased states. We employ a comprehensive, five-step approach , developing innovative methodologies and applying them across multiple systems to empower more mechanistic inquiry and a deeper understanding of the rules that govern ensemble cellular behaviors.

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Featured Publications

Allergic Inflammatory Memory in Human Respiratory Epithelial Progenitor Cells
  • Ordovas-Montanes J. et al.,
  • Nature,
  • 2018
Biology
Cell Atlas
Immunology
Medicine
José Ordovas-Montañes
Sarah Nyquist
Travis Hughes
Marc Wadsworth
Sam Kazer
Alex K. Shalek

We used single-cell RNA-seq to uncover basal cell reprogramming in allergic airway disease.

Seq-Well is a portable and inexpensive platform for high-throughput single-cell RNA sequencing. We report robust single-cell transcriptional profiling on cell lines and primary human cells.

Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput
  • Gierahn et al.,
  • Nature Methods,
  • 2017
Chemistry
Genomics
R&D
Technology
Travel
Marc Wadsworth
Travis Hughes
Alex K. Shalek

News

Kellie Kolb Graduates from the Shalek Lab!

June 6, 2019

Congratulations to Kellie Kolb, the first student from the Shalek Lab to receive her PhD! We wish Kellie the best of luck in her future endeavors, and we're excited for many more graduations in the coming years!

Our Paper on Tuberculosis Infection Featured in NIH News

June 6, 2019

A recent paper published in Nature from the Shalek lab and collaborators was featured in NIH News. Ardain et. al. demonstrate that group 3 innate lymphoid cells localize to the lungs soon after M. tuberculosis infection, providing an early line of defense against tuberculosis (TB). This understanding of the initial…