Our Research

Research in the Shalek Lab is directed towards the creation and implementation of new technologies to understand how cells collectively perform systems-level functions in healthy and diseased states. We employ a comprehensive, five-step approach , developing innovative methodologies and applying them across multiple systems to empower more mechanistic inquiry and a deeper understanding of the rules that govern ensemble cellular behaviors.

This slideshow requires JavaScript.

Featured Publications

Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput

Gierahn et al.,
Nature Methods,
2017

Chemistry

Genomics

R&D

Technology

Travel

Marc Wadsworth

Travis Hughes

Alex K. Shalek

Seq-Well is a portable and inexpensive platform for high-throughput single-cell RNA sequencing. We report robust single-cell transcriptional profiling on cell lines and primary human cells.

We applied single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 Melanoma patients, profiling malignant, immune, stromal, and endothelial cells.