Research in the Shalek Lab is directed towards the creation and implementation of new technologies to understand how cells collectively perform systems-level functions in healthy and diseased states. We employ a comprehensive, five-step approach , developing innovative methodologies and applying them across multiple systems to empower more mechanistic inquiry and a deeper understanding of the rules that govern ensemble cellular behaviors.
Our Research
Featured Publications
Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput
Chemistry
Genomics
R&D
Technology
Travel
Marc Wadsworth
Travis Hughes
Alex K. ShalekSeq-Well is a portable and inexpensive platform for high-throughput single-cell RNA sequencing. We report robust single-cell transcriptional profiling on cell lines and primary human cells.
We applied single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 Melanoma patients, profiling malignant, immune, stromal, and endothelial cells.
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
Biology
CancerGenomics
Medicine
Jay PrakadanMarc Wadsworth
Alex GenshaftTravis Hughes
Carly Ziegler
Sam Kazer
Aleth Gaillard
Kellie KolbAlex K. ShalekNews
Alex Shalek Named Pew-Stewart Scholar for Cancer Research
Research in the Shalek Lab is directed towards the creation and implementation of new technologies to understand how cells collectively perform systems-level functions in healthy and diseased states. We employ a comprehensive, five-step approach , developing innovative methodologies and applying...
Shalek Lab Featured in Nature!
Research in the Shalek Lab is directed towards the creation and implementation of new technologies to understand how cells collectively perform systems-level functions in healthy and diseased states. We employ a comprehensive, five-step approach , developing innovative methodologies and applying...
Welcome Conner and Michelle!
Research in the Shalek Lab is directed towards the creation and implementation of new technologies to understand how cells collectively perform systems-level functions in healthy and diseased states. We employ a comprehensive, five-step approach , developing innovative methodologies and applying...