We’re stoked to have this paper up! We present our work finding new roles for sensory neurons within inflammatory responses and previously unappreciated axes of neuro-immune crosstalk. Led by Shalek lab MD-PhD student Carly Ziegler and post doc Tracy Huang with Uli von Andrian, we find that lymph nodes are not only innervated by sensory neurons (!!) but these neurons are poised to interact with specific cells and structures within the lymph node, and potentially locally modulate immune activity. By linking optogenetic stimulation with a transcriptomic read out, we start to map out this complex circuit. More to come! Pre-print found here.
New Paper on Neuroimmune Interactions on BioRxiv