Jay Prakadan

Former Graduate Student

Degrees & Affiliations

BS, Chemistry - University of Chicago PhD, Chemistry - MIT

Background & Interests

Biography

Sanjay (Jay) M. Prakadan is a physical chemistry doctoral candidate in the Department of Chemistry at the Massachusetts Institute of Technology (MIT), and is co-appointed at the Ragon and Broad Institutes. His current research, under the guidance of Alex K. Shalek at the Institute for Medical Engineering and Science (IMES), focuses on developing techniques to probe single-cell behaviors at the genomic scale, application of single-cell tools to clinical liquid biopsy samples, and realizing computational frameworks to inform single-cell genomic analyses with additional cellular metadata. Sanjay received his bachelor’s degree with honors in Chemistry from the University of Chicago.

Publications

Hepatic adaptation to chronic metabolic stress primes tumorigenesis

Tzouanas et al.,
Cell,
2026

Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival

Tzouanas et al.,
bioRxiv,
2023

PI3Kβ controls immune evasion in PTEN-deficient breast tumours

Bergholz et al.,
Nature,
2023

Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases

Prakadan et al.,
Nature Communications,
2021

MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection

Khuzwayo et al.,
Frontiers in Immunology,
2021

Mechanisms of lymphoma clearance induced by high-dose alkylating agents

Lossos et al.,
Cancer Discovery,
2019

Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer

Hamza B. et al.,
PNAS,
2019

Linking single-cell measurements of mass, growth rate, and gene expression

Kimmerling R.J. et al.,
Genome Biology,
2018

IFNγ-Dependent Tissue-Immune Homeostasis is Co-opted in the Tumor Microenvironment

Nirschl et al.,
Cell,
2017

Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices

Prakadan et al.,
Nature Reviews Genetics,
2017