Biography

Sanjay (Jay) M. Prakadan is a physical chemistry doctoral candidate in the Department of Chemistry at the Massachusetts Institute of Technology (MIT), and is co-appointed at the Ragon and Broad Institutes. His current research, under the guidance of Alex K. Shalek at the Institute for Medical Engineering and Science (IMES), focuses on developing techniques to probe single-cell behaviors at the genomic scale, application of single-cell tools to clinical liquid biopsy samples, and realizing computational frameworks to inform single-cell genomic analyses with additional cellular metadata. Sanjay received his bachelor’s degree with honors in Chemistry from the University of Chicago.

Publications

PI3Kβ controls immune evasion in PTEN-deficient breast tumours
  • Bergholz et al.,
  • Nature,
  • 2023
  • Medicine
  • Biology
  • Genomics
  • Cancer
  • Immunology
  • Michelle Ramseier
  • Jay Prakadan
  • Alex K. Shalek
Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases
  • Prakadan et al.,
  • Nature Communications,
  • 2021
  • Cancer
  • Immunology
  • Genomics
  • Biology
  • Medicine
  • Jay Prakadan
  • Andrew Navia
  • Kellie Kolb
  • Marc Wadsworth II
  • Alex K. Shalek
MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection
  • Khuzwayo et al.,
  • Frontiers in Immunology,
  • 2021
  • Biology
  • Microbiology
  • Genomics
  • Infectious Disease
  • Immunology
  • Jay Prakadan
  • Sam Kazer
  • Alex K. Shalek
Mechanisms of lymphoma clearance induced by high-dose alkylating agents
  • Lossos et al.,
  • Cancer Discovery,
  • 2019
  • Cancer
  • Immunology
  • Biology
  • Kellie Kolb
  • Jay Prakadan
  • Alex K. Shalek
Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer
  • Hamza B. et al.,
  • PNAS,
  • 2019
  • Cancer
  • Technology
  • R&D
  • Computational Methods
  • Biology
  • Jay Prakadan
  • Andrew Navia
  • Peter Winter
  • Riley Drake
  • Alejandro Gupta
  • Alex K. Shalek
Linking single-cell measurements of mass, growth rate, and gene expression
  • Kimmerling R.J. et al.,
  • Genome Biology,
  • 2018
  • Genomics
  • Physics
  • R&D
  • Cancer
  • Biology
  • Technology
  • Jay Prakadan
  • Alejandro Gupta
  • Riley Drake
  • Alex K. Shalek
Linking single-cell measurements of mass, growth rate, and gene expression
  • Kimmerling et al.,
  • BioRxiv,
  • 2018
  • Technology
  • Genomics
  • Chemistry
  • Jay Prakadan
  • Alejandro Gupta
  • Riley Drake
  • Alex K. Shalek
IFNγ-Dependent Tissue-Immune Homeostasis is Co-opted in the Tumor Microenvironment
  • Nirschl et al.,
  • Cell,
  • 2017
  • Genomics
  • Immunology
  • Cancer
  • Jay Prakadan
  • Alex K. Shalek
Scaling by shrinking: empowering single-cell ‘omics’ with microfluidic devices
  • Prakadan et al.,
  • Nature Reviews Genetics,
  • 2017
  • Technology
  • Genomics
  • Jay Prakadan
  • Alex K. Shalek
Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction
  • Genshaft et al.,
  • Genome Biology,
  • 2016
  • Chemistry
  • R&D
  • Biology
  • Technology
  • Genomics
  • Alex Genshaft
  • Jay Prakadan
  • Carly Ziegler
  • Alex K. Shalek
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
  • Tirosh et al.,
  • Science,
  • 2016
  • Medicine
  • Biology
  • Cancer
  • Genomics
  • Jay Prakadan
  • Marc Wadsworth II
  • Alex Genshaft
  • Travis Hughes
  • Carly Ziegler
  • Sam Kazer
  • Aleth Gaillard
  • Kellie Kolb
  • Alex K. Shalek