The full expression matrix and associated metadata from the publication “Integrated Single-Cell Analysis of Multicellular Immune Dynamics during Hyperacute HIV-1 Infection” can be downloaded from the Alexandria Project hosted through the Single Cell Portal at the Broad Institute. Please visit the interactive dataset here to access and explore the data online. See below for an extended Supplementary Discussion contextualizing our findings in the single-cell transcriptomics and HIV literature. Supplementary Software is available for download on this page.