Alex K. Shalek

Alex K. Shalek

Background & Interests

Biology Biology
Chemistry Chemistry
Genomics Genomics
Getting Swole Getting Swole
Hot Stuff Hot Stuff
I Want a Hot Body, but I also Want Tacos I Want a Hot Body, but I also Want Tacos
Immunology Immunology
R&D R&D
Top Shelf Top Shelf

Biography

Alex K. Shalek, PhD, is the Director of the Institute for Medical Engineering & Science (IMES), the Director of the Health Innovation Hub at MIT, and he is the J. W. Kieckhefer Professor in IMES and the Department of Chemistry at MIT, as well as an Extramural Member of its Koch Institute for Integrative Cancer Research.  He is also an Institute Member of the Broad Institute, a Member of the Ragon Institute, an Assistant in Immunology at MGB, and an Instructor in Health Sciences & Technology at HMS. Dr. Shalek received his bachelor’s degree summa cum laude from Columbia University and his Ph.D. from Harvard University in chemical physics under the guidance of Hongkun Park, and performed postdoctoral training under Hongkun Park and Aviv Regev (Broad/MIT). His lab’s research is directed towards the development and application of new approaches to elucidate cellular and molecular features that inform tissue-level function and dysfunction across the spectrum of human health and disease. Dr. Shalek and his work have received numerous honors including a NIH New Innovator Award, a Beckman Young Investigator Award, a Searle Scholar Award, a Pew-Stewart Scholar Award, the Avant-Garde (DP1 Pioneer) Award from the National Institute for Drug Abuse (NIDA), and an Alfred P. Sloan Research Fellowship in Chemistry, as well as the 2019-2020 Harold E. Edgerton Faculty Achievement Award at MIT and the 2020 HMS Young Mentor Award.

Publications

  • Li et al.,
  • bioRxiv,
  • 2026
Computational Methods Computational Methods
Genomics Genomics
Technology Technology
Alex K. Shalek Alex K. Shalek
Ankit Basak Ankit Basak
  • Russo et al.,
  • Nature Protocols,
  • 2026
Computational Methods Computational Methods
Genomics Genomics
Technology Technology
Alex K. Shalek Alex K. Shalek
Brittany Goods Brittany Goods
Daniela Russo Daniela Russo
Sarah Quinn Sarah Quinn
Sergio Triana Sergio Triana
  • Tong et al.,
  • medRxiv,
  • 2026
Genomics Genomics
Immunology Immunology
Infectious Disease Infectious Disease
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Daniela Russo Daniela Russo
Evelyn Yuzhou Tong Evelyn Yuzhou Tong
Sergio Triana Sergio Triana
  • Basak et al.,
  • bioRxiv,
  • 2026
Cancer Cancer
Computational Methods Computational Methods
Genomics Genomics
Alex K. Shalek Alex K. Shalek
Ankit Basak Ankit Basak
Bokai Zhu Bokai Zhu
Constantine Tzouanas Constantine Tzouanas
Evelyn Yuzhou Tong Evelyn Yuzhou Tong
Feng Shan Feng Shan
Sarah Sweeting Sarah Sweeting
Sidney Allison Sidney Allison
Somkene 'DK' Alakwe Somkene 'DK' Alakwe
  • Severson et al.,
  • Journal of Thoracic Oncology,
  • 2026
Cancer Cancer
Computational Methods Computational Methods
Medicine Medicine
Alex K. Shalek Alex K. Shalek
Travis Hughes Travis Hughes
  • Mbano. et al.,
  • Journal of Experimental Medicine,
  • 2026
Computational Methods Computational Methods
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Ivy Liu Ivy Liu
Josh Bromley Josh Bromley
Marc Wadsworth II Marc Wadsworth II
Sergio Triana Sergio Triana
Travis Hughes Travis Hughes
  • Nettey et al.,
  • medRxiv,
  • 2025
Immunology Immunology
Medicine Medicine
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Kyle Kimler Kyle Kimler
Leonard Nettey Leonard Nettey
Zoë Steier Zoë Steier
  • DeMeo et al.,
  • Science,
  • 2025
Computational Methods Computational Methods
Genomics Genomics
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
  • Xu et al.,
  • Journal of Experimental Medicine,
  • 2025
Genomics Genomics
Immunology Immunology
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Tyler Dao Tyler Dao
  • Adhikari et al.,
  • Cell,
  • 2025
Computational Methods Computational Methods
Immunology Immunology
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Sarah Nyquist Sarah Nyquist