Alex K. Shalek

Alex K. Shalek

Background & Interests

Biology Biology
Chemistry Chemistry
Genomics Genomics
Getting Swole Getting Swole
Hot Stuff Hot Stuff
I Want a Hot Body, but I also Want Tacos I Want a Hot Body, but I also Want Tacos
Immunology Immunology
R&D R&D
Top Shelf Top Shelf

Biography

Alex K. Shalek, PhD, is the J. W. Kieckhefer Professor in the Institute for Medical Engineering & Science and the Department of Chemistry, and an Extramural Member of The Koch Institute for Integrative Cancer Research at MIT. He is also an Institute Member of the Broad Institute, a Member of the Ragon Institute, an Assistant in Immunology at MGB, and an Instructor in Health Sciences & Technology at HMS. Dr. Shalek received his bachelor’s degree summa cum laude from Columbia University and his Ph.D. from Harvard University in chemical physics under the guidance of Hongkun Park, and performed postdoctoral training under Hongkun Park and Aviv Regev (Broad/MIT). His lab’s research is directed towards the development and application of new approaches to elucidate cellular and molecular features that inform tissue-level function and dysfunction across the spectrum of human health and disease. Dr. Shalek and his work have received numerous honors including a NIH New Innovator Award, a Beckman Young Investigator Award, a Searle Scholar Award, a Pew-Stewart Scholar Award, the Avant-Garde (DP1 Pioneer) Award from the National Institute for Drug Abuse (NIDA), and an Alfred P. Sloan Research Fellowship in Chemistry, as well as the 2019-2020 Harold E. Edgerton Faculty Achievement Award at MIT and the 2020 HMS Young Mentor Award.

Publications

Mutation and cell state compatibility is required and targetable in Ph+ acute lymphoblastic leukemia minimal residual disease
Mutation and cell state compatibility is required and targetable in Ph+ acute lymphoblastic leukemia minimal residual disease
  • Winter et al.,
  • Biorxiv,
  • 2024
Cancer Cancer
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Charles P. Couturier Charles P. Couturier
Jennyfer Galvez-Reyes Jennyfer Galvez-Reyes
Michelle Ramseier Michelle Ramseier
Nolawit Mulugeta Nolawit Mulugeta
Peter Winter Peter Winter
Impact of variants and vaccination on nasal immunity across three waves of SARS-CoV-2
Impact of variants and vaccination on nasal immunity across three waves of SARS-CoV-2
  • Long et al.,
  • biorxiv,
  • 2024
Infectious Disease Infectious Disease
Medicine Medicine
Andrew Navia Andrew Navia
Carly Ziegler Carly Ziegler
Josh Bromley Josh Bromley
José Ordovas-Montañes José Ordovas-Montañes
Kyle Kimler Kyle Kimler
Micayla George Micayla George
Riley Drake Riley Drake
Samira Ibrahim Samira Ibrahim
Tasneem Jivanjee Tasneem Jivanjee
Vincent Miao Vincent Miao
Comprehensive multi-site profiling of the malignant pleural mesothelioma micro-environment identifies candidate molecular determinants of histopathologic type
Comprehensive multi-site profiling of the malignant pleural mesothelioma micro-environment identifies candidate molecular determinants of histopathologic type
  • Severson et al.,
  • biorxiv,
  • 2024
Cancer Cancer
Computational Methods Computational Methods
Alex K. Shalek Alex K. Shalek
Travis Hughes Travis Hughes
Systematic deconstruction of myeloid cell signaling in tuberculosis granulomas reveals IFN-γ, TGF-β, and time are associated with conserved myeloid diversity
Systematic deconstruction of myeloid cell signaling in tuberculosis granulomas reveals IFN-γ, TGF-β, and time are associated with conserved myeloid diversity
  • Peters et al.,
  • biorxiv,
  • 2024
Alex K. Shalek Alex K. Shalek
Josh Bromley Josh Bromley
Sarah Nyquist Sarah Nyquist
Travis Hughes Travis Hughes
Single-cell and spatiotemporal profile of ovulation in the mouse ovary
Single-cell and spatiotemporal profile of ovulation in the mouse ovary
  • Huang et al.,
  • bioRxiv,
  • 2024
Biology Biology
Computational Methods Computational Methods
Alex K. Shalek Alex K. Shalek
Brittany Goods Brittany Goods
Daniela Russo Daniela Russo
Intrahepatic plasma cells, but not atypical memoryB cells, associate with clinical phases of chronichepatitis B
Intrahepatic plasma cells, but not atypical memoryB cells, associate with clinical phases of chronichepatitis B
  • Osmani et al.,
  • European Journal of Immunology,
  • 2024
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Jasmin Joseph-Chazan Jasmin Joseph-Chazan
B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles
B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles
  • Krause et al.,
  • Nature Communications,
  • 2024
Biology Biology
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Cross-domain information fusion for enhanced cell population delineation in single-cell spatial-omics data
Cross-domain information fusion for enhanced cell population delineation in single-cell spatial-omics data
  • Zhu et al.,
  • bioRxiv,
  • 2024
Computational Methods Computational Methods
Alex K. Shalek Alex K. Shalek
Bokai Zhu Bokai Zhu
An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection
An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection
  • Ziegler et al.,
  • American Society for Microbiology,
  • 2024
Computational Methods Computational Methods
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Carly Ziegler Carly Ziegler
Josh Bromley Josh Bromley
José Ordovas-Montañes José Ordovas-Montañes
Micayla George Micayla George
Riley Drake Riley Drake
Sam Kazer Sam Kazer
Vincent Miao Vincent Miao
A knockoff calibration method to avoid over-clustering in single-cell RNA-sequencing
A knockoff calibration method to avoid over-clustering in single-cell RNA-sequencing
  • DenAdel et al.,
  • bioRxiv,
  • 2024
Computational Methods Computational Methods
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Michelle Ramseier Michelle Ramseier
Peter Winter Peter Winter