Alex K. Shalek

Alex K. Shalek

Background & Interests

Biology Biology
Chemistry Chemistry
Genomics Genomics
Getting Swole Getting Swole
Hot Stuff Hot Stuff
I Want a Hot Body, but I also Want Tacos I Want a Hot Body, but I also Want Tacos
Immunology Immunology
R&D R&D
Top Shelf Top Shelf

Biography

Alex K. Shalek, PhD, is the J. W. Kieckhefer Professor in the Institute for Medical Engineering & Science and the Department of Chemistry, and an Extramural Member of The Koch Institute for Integrative Cancer Research at MIT. He is also an Institute Member of the Broad Institute, a Member of the Ragon Institute, an Assistant in Immunology at MGB, and an Instructor in Health Sciences & Technology at HMS. Dr. Shalek received his bachelor’s degree summa cum laude from Columbia University and his Ph.D. from Harvard University in chemical physics under the guidance of Hongkun Park, and performed postdoctoral training under Hongkun Park and Aviv Regev (Broad/MIT). His lab’s research is directed towards the development and application of new approaches to elucidate cellular and molecular features that inform tissue-level function and dysfunction across the spectrum of human health and disease. Dr. Shalek and his work have received numerous honors including a NIH New Innovator Award, a Beckman Young Investigator Award, a Searle Scholar Award, a Pew-Stewart Scholar Award, the Avant-Garde (DP1 Pioneer) Award from the National Institute for Drug Abuse (NIDA), and an Alfred P. Sloan Research Fellowship in Chemistry, as well as the 2019-2020 Harold E. Edgerton Faculty Achievement Award at MIT and the 2020 HMS Young Mentor Award.

Publications

scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria
scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria
  • Morang’a et al.,
  • Experimental Biology and Medicine,
  • 2025
Computational Methods Computational Methods
Infectious Disease Infectious Disease
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Riley Drake Riley Drake
Deep profiling deconstructs features associated with memory CD8+ T cell tissue residence
Deep profiling deconstructs features associated with memory CD8+ T cell tissue residence
  • Scott et al.,
  • Immunity,
  • 2024
Computational Methods Computational Methods
Immunology Immunology
Alex K. Shalek Alex K. Shalek
Zoë Steier Zoë Steier
Scalable, compressed phenotypic screeningusing pooled perturbations
Scalable, compressed phenotypic screeningusing pooled perturbations
  • Liu et al.,
  • Nature Biotechnology,
  • 2024
Biology Biology
Cancer Cancer
Immunology Immunology
Microbiology Microbiology
R&D R&D
Technology Technology
Alex K. Shalek Alex K. Shalek
Ben Mead Ben Mead
Conner Kummerlowe Conner Kummerlowe
Ivy Liu Ivy Liu
Manny Guzman Manny Guzman
Sarah Ingabire Sarah Ingabire
Sergio Triana Sergio Triana
Walaa Kattan Walaa Kattan
B-cell–directed CAR T-cell therapy activates CD8+ cytotoxic CARneg bystander T cells in patients and nonhuman primates
B-cell–directed CAR T-cell therapy activates CD8+ cytotoxic CARneg bystander T cells in patients and nonhuman primates
  • Kaminski et al.,
  • Blood,
  • 2024
Computational Methods Computational Methods
Immunology Immunology
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Jim Kaminski Jim Kaminski
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection
  • Bromley et al.,
  • Immunity,
  • 2024
Computational Methods Computational Methods
Immunology Immunology
Infectious Disease Infectious Disease
Alex K. Shalek Alex K. Shalek
Josh Bromley Josh Bromley
Sarah Nyquist Sarah Nyquist
LAT encodes T cell activation pathway balance
LAT encodes T cell activation pathway balance
  • Rubin et al.,
  • bioRxiv,
  • 2024
Computational Methods Computational Methods
Immunology Immunology
Microbiology Microbiology
Adam Rubin Adam Rubin
Alex K. Shalek Alex K. Shalek
Tyler Dao Tyler Dao
Distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense
Distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense
  • Wellford et al.,
  • Mucosal Immunology,
  • 2024
Infectious Disease Infectious Disease
Medicine Medicine
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
José Ordovas-Montañes José Ordovas-Montañes
Marko Vukovic Marko Vukovic
Mutation and cell state compatibility is required and targetable in Ph+ acute lymphoblastic leukemia minimal residual disease
Mutation and cell state compatibility is required and targetable in Ph+ acute lymphoblastic leukemia minimal residual disease
  • Winter et al.,
  • Biorxiv,
  • 2024
Cancer Cancer
Microbiology Microbiology
Alex K. Shalek Alex K. Shalek
Andrew Navia Andrew Navia
Charles P. Couturier Charles P. Couturier
Jennyfer Galvez-Reyes Jennyfer Galvez-Reyes
Michelle Ramseier Michelle Ramseier
Nolawit Mulugeta Nolawit Mulugeta
Peter Winter Peter Winter
Impact of variants and vaccination on nasal immunity across three waves of SARS-CoV-2
Impact of variants and vaccination on nasal immunity across three waves of SARS-CoV-2
  • Long et al.,
  • biorxiv,
  • 2024
Infectious Disease Infectious Disease
Medicine Medicine
Andrew Navia Andrew Navia
Carly Ziegler Carly Ziegler
Josh Bromley Josh Bromley
José Ordovas-Montañes José Ordovas-Montañes
Kyle Kimler Kyle Kimler
Micayla George Micayla George
Riley Drake Riley Drake
Samira Ibrahim Samira Ibrahim
Tasneem Jivanjee Tasneem Jivanjee
Vincent Miao Vincent Miao
Comprehensive multi-site profiling of the malignant pleural mesothelioma micro-environment identifies candidate molecular determinants of histopathologic type
Comprehensive multi-site profiling of the malignant pleural mesothelioma micro-environment identifies candidate molecular determinants of histopathologic type
  • Severson et al.,
  • biorxiv,
  • 2024
Cancer Cancer
Computational Methods Computational Methods
Alex K. Shalek Alex K. Shalek
Travis Hughes Travis Hughes