Degrees & Affiliations
BS, Bioengineering - Rice University PhD Student, Medical Engineering & Medical Physics - Harvard-MIT Health Sciences & Technology
Background & Interests





Biography
Constantine Tzouanas is a Hertz Fellow and NSF Graduate Research Fellow in the Harvard-MIT Health Sciences and Technology program, pursuing a PhD in Medical Engineering and Medical Physics with a concentration in Biological Engineering.
In the Shalek lab, he researches how the properties and interactions of individual cells produce the emergent phenomena needed for tissue/organism-level function, but go awry in disease states. His work combines technology development, bioinformatics, and wet lab experimentation to bring hard engineering rigor to the squishy world of biology.
As an undergraduate at Rice University, he majored in Bioengineering and minored in Neuroscience. He received the Goldwater Scholarship and worked on circuit neuroscience in the lab of Prof. Jacob Robinson, developing microfluidic devices to uncover principles of neural plasticity in the immortal jellyfish Hydra vulgaris.
Outside of research and coursework at MIT and Harvard, Constantine serves as an officer of the MIT Biotech Group and in the Harvard-MIT Health Sciences and Technology Joint Council. In his free time, Constantine enjoys running, ultimate frisbee, and baking. As mildly interesting trivia facts, his current favorite upbeat indie band is Saint Motel, and his childhood dream job was to become a skyscraper architect.
Publications

Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis







Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival










Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients















Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control















Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity

















Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes










High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity





SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues

















SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is enriched in specific cell subsets across tissues


















Spatially-resolved live cell tagging and isolation using protected photoactivatable cell dyes











